SCHEMBL9803535

SCHEMBL9803535

CCOc1ccc(-c2ccc(OC(=O)C(Cl)CC(C)C)cc2)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACACB O00763 1/20 0.45
ACACA Q13085 1/20 0.45
HPGD P15428 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
PTGS2 P35354 1/20 0.42
PARP10 Q53GL7 1/20 0.41
MAPT P10636 1/20 0.40
GAA P10253 2/20 0.40
NQO1 P15559 1/20 0.40
MEN1 O00255 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2D6 P10635 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40
KMT2A Q03164 1/20 0.40
AKR1C3 P42330 1/20 0.40
AKR1C2 P52895 1/20 0.40
CHRNA7 P36544 1/20 0.39
TAS1R3 Q7RTX0 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9857848 0.91 ELANE (0.43) PTGS2MAPTGAAMEN1CYP1A2
SCHEMBL9803374 0.89 RARB (0.48) ACACBACACANPSR1CYP1A2CYP3A4
SCHEMBL9803511 0.89 TAS1R3 (0.49) ACACBACACACYP1A2CYP2C19KMT2A
SCHEMBL9803621 0.87 RARB (0.52) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL9803639 0.85 RARB (0.54) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL9802921 0.85 RARB (0.54) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL9803349 0.85 RARB (0.54) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL9803575 0.85 RARB (0.54) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL9803347 0.85 RARB (0.54) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL9803567 0.85 RARB (0.54) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0159872-B1 SMECTIC LIQUID CRYSTAL COMPOUND AND LIQUID CRYSTAL COMPOSITIONS AJINOMOTO CO., INC. (JP) 1991-03-06 EP disclosed
US-4592858-A HIGH SPEED FERROELECTRIC SWITCHES AJINOMOTO COMPANY, INC. (JP) 1986-06-03 US disclosed
EP-0159872-A2 Smectic liquid crystal compound and liquid crystal compositions AJINOMOTO CO., INC. (JP) 1985-10-30 EP disclosed