SCHEMBL9804067

SCHEMBL9804067

O=C(NC(=O)c1ccccc1Cl)Nc1ccc(OC(F)(F)C(F)OC(F)(F)C(F)(F)F)cc1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 2/20 0.71
GCGR P47871 1/20 0.49
RAB9A P51151 3/20 0.48
ALDH1A1 P00352 3/20 0.48
RORC P51449 1/20 0.48
PLCG2 P16885 1/20 0.44
NPC1 O15118 2/20 0.44
POLB P06746 2/20 0.44
PKM P14618 1/20 0.44
GAA P10253 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
MAPT P10636 1/20 0.42
PCTP Q9UKL6 1/20 0.42
GHSR Q92847 1/20 0.41
EPHX2 P34913 2/20 0.40
PYGL P06737 3/20 0.40
CA1 P00915 1/20 0.40
CA2 P00918 1/20 0.40
CA9 Q16790 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10711181 0.89 TDP1 (0.72) TDP1GCGRRAB9AALDH1A1RORC
SCHEMBL10800847 0.88 TDP1 (0.82) TDP1GCGRRAB9AALDH1A1RORC
SCHEMBL9804126 0.88 TDP1 (0.53) TDP1GCGRRAB9AALDH1A1RORC
SCHEMBL10590129 0.87 TDP1 (0.53) TDP1GCGRRAB9AALDH1A1RORC
SCHEMBL10710076 0.85 TDP1 (0.77) TDP1GCGRRAB9AALDH1A1RORC
SCHEMBL515847 0.85 TDP1 (0.80) TDP1GCGRRAB9AALDH1A1RORC
SCHEMBL27847099 0.84 TDP1 (0.78) TDP1GCGRRAB9AALDH1A1RORC
Triflumuron SCHEMBL23700 0.83 TDP1 (1.00) TDP1GCGRRAB9AALDH1A1RORC
Triflumuron SCHEMBL9490691 0.83 TDP1 (1.00) TDP1GCGRRAB9AALDH1A1RORC
Triflumuron SCHEMBL29832813 0.83 TDP1 (1.00) TDP1GCGRRAB9AALDH1A1RORC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0203618-B1 BENZOYL-UREAS HAVING INSECTICIDE ACTIVITY ISTITUTO GUIDO DONEGANI S.p.A. (IT) 1991-04-17 EP claimed
US-4980376-A LARVICIDES; ANTIFERTILITY AGENTS ISTITUTO GUIDO DONEGANI S.P.A. (IT) 1990-12-25 US claimed
EP-0203618-A2 Benzoyl-ureas having insecticide activity ISTITUTO GUIDO DONEGANI S.p.A. (IT) 1986-12-03 EP claimed
EP-0203618-B1 BENZOYL-UREAS HAVING INSECTICIDE ACTIVITY ISTITUTO GUIDO DONEGANI S.p.A. (IT) 1991-04-17 EP disclosed
US-4980376-A LARVICIDES; ANTIFERTILITY AGENTS ISTITUTO GUIDO DONEGANI S.P.A. (IT) 1990-12-25 US disclosed
EP-0203618-A2 Benzoyl-ureas having insecticide activity ISTITUTO GUIDO DONEGANI S.p.A. (IT) 1986-12-03 EP disclosed