Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | EPOR | P19235 | 3/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 3/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10446491 | 1.00 | TTR (0.38) | TTREPORHRH1BACE1ALOX5 | |
| SCHEMBL10446493 | 0.90 | EPOR (0.38) | TTREPORHRH1BACE1ALOX5 | |
| SCHEMBL9804304 | 0.80 | ALDH1A1 (0.42) | TTREPORHRH1BACE1ALOX5 | |
| SCHEMBL29110079 | 0.80 | EPOR (0.40) | TTREPORHRH1BACE1ALOX5 | |
| SCHEMBL9496444 | 0.80 | TTR (0.39) | TTREPORHRH1BACE1ALOX5 | |
| SCHEMBL9496431 | 0.80 | TTR (0.39) | TTREPORHRH1BACE1ALOX5 | |
| SCHEMBL29110082 | 0.80 | EPOR (0.40) | TTREPORHRH1BACE1ALOX5 | |
| SCHEMBL9492703 | 0.77 | TTR (0.40) | TTREPORBACE1ALOX5ALOX5AP | |
| SCHEMBL29110085 | 0.75 | ALDH1A1 (0.50) | TTRALDH1A1MAPTMAPK1L3MBTL1 | |
| SCHEMBL10489447 | 0.75 | ALDH1A1 (0.50) | TTRALDH1A1MAPTMAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0240121-B1 | DIPHENYL ETHER DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-04-17 | — | — | EP | disclosed |
| EP-0390228-A2 | Chemical intermediates | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-10-03 | — | — | EP | disclosed |
| US-4791139-A | Diphenyl ether derivatives and their use as insecticides | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-12-13 | — | — | US | disclosed |
| EP-0240121-A2 | Diphenyl ether derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1987-10-07 | — | — | EP | disclosed |