⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28146195 | 1.00 | — | — | |
| SCHEMBL27988420 | 1.00 | — | — | |
| SCHEMBL1928901 | 0.92 | — | — | |
| SCHEMBL5005539 | 0.78 | — | — | |
| SCHEMBL27993266 | 0.77 | — | — | |
| SCHEMBL3630149 | 0.73 | — | — | |
| SCHEMBL14013414 | 0.67 | — | — | |
| SCHEMBL737276 | 0.67 | FAAH (0.35) | — | |
| SCHEMBL738222 | 0.65 | PHGDH (0.39) | — | |
| SCHEMBL386696 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 78 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107148419-A | The inhibitor of ZESTE enhancers homologue 2 | 葛兰素史密斯克莱知识产权（第2 号）有限公司 | 2017-09-08 | — | — | CN | claimed |
| CN-104974161-A | 4H-pyrazolo[1,5-[alpha]]benzimidazole compound analogue as PARP inhibitor | NANJING MINGDE NEW DRUG RES AND DEV CO LTD | 2015-10-14 | — | — | CN | claimed |
| CN-116635028-A | Modulators of c-MYC mRNA translation and their use in the treatment of cancer | 艾尼莫生物科技公司 | 2023-08-22 | — | — | CN | disclosed |
| US-10787433-B2 | Pyridazine derivatives as EAAT2 activators | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2020-09-29 | — | — | US | disclosed |
| CN-110041250-A | The benzene compound being substituted | EPIZYME股份有限公司 | 2019-07-23 | — | — | CN | disclosed |
| US-20190040040-A1 | PYRIDAZINE DERIVATIVES AS EAAT2 ACTIVATORS | OHIO STATE UNIVERSITY | 2019-02-07 | — | — | US | disclosed |
| CN-105102432-B | Substituted Benzene Compounds | EPIZYME股份有限公司 | 2019-01-04 | — | — | CN | disclosed |
| CN-109071524-A | Pyridyl derivatives as EAAT2 activator | 布里格姆及妇女医院股份有限公司 | 2018-12-21 | — | — | CN | disclosed |
| EP-3402793-A1 | PYRIDAZINE DERIVATIVES AS EAAT2 ACTIVATORS | The Brigham and Women's Hospital, Inc. (US) | 2018-11-21 | — | — | EP | disclosed |
| CN-105308038-B | The inhibitor of Zeste enhancers homologue 2 | 葛兰素史密斯克莱知识产权（第2 号）有限公司 | 2018-05-29 | — | — | CN | disclosed |
| CN-107148419-A | The inhibitor of ZESTE enhancers homologue 2 | 葛兰素史密斯克莱知识产权（第2 号）有限公司 | 2017-09-08 | — | — | CN | disclosed |
| US-5272268-A | Dipeptide derivatives | SHIONOGI & CO., LTD. (JP) | 1993-12-21 | — | — | US | disclosed |
| US-5223615-A | Hypotensive agents | SHIONOGI & CO., LTD. (JP) | 1993-06-29 | — | — | US | disclosed |
| US-5194608-A | Hypotensive agents; inhibits renin-angiotensin system | SHIONOGI & CO., LTD. (JP) | 1993-03-16 | — | — | US | disclosed |
| EP-0468641-A2 | Renin inhibiting dipeptide derivatives, their preparation and pharmaceutical preparations containing them | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) | 1992-01-29 | — | — | EP | disclosed |
| EP-0057362-B1 | DIBENZOFURANE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS FUNGICIDES | BASF Aktiengesellschaft (DE) | 1984-06-20 | — | — | EP | disclosed |
| EP-0103277-A1 | Quaternary ammonium salts of benzofuran derivatives and fungicides containing them | BASF Aktiengesellschaft (DE) | 1984-03-21 | — | — | EP | disclosed |
| US-4376776-A | Dibenzofuran derivatives and their use for controlling fungi | BASF AKTIENGESELLSCHAFT (DE) | 1983-03-15 | — | — | US | disclosed |
| EP-0057362-A1 | Dibenzofurane derivatives, process for their preparation and their use as fungicides | BASF Aktiengesellschaft (DE) | 1982-08-11 | — | — | EP | disclosed |
| EP-0008343-A1 | Cephalosporin derivatives, processes for their preparation and pharmaceutical compositions containing them | CIBA-GEIGY AG (CH) | 1980-03-05 | — | — | EP | disclosed |