Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | CCR8 | P51685 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.39 |
| ▸ | FDFT1 | P37268 | 2/20 | 0.39 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.39 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.39 |
| ▸ | CETP | P11597 | 3/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9804529 | 1.00 | PPARG (0.44) | PPARGPPARACCR8KCNH2DAGLA | |
| SCHEMBL7932271 | 0.92 | AKR1C3 (0.42) | MAPK14LMNAFDFT1CETPALDH1A1 | |
| SCHEMBL7932267 | 0.92 | AKR1C3 (0.42) | MAPK14LMNAFDFT1CETPALDH1A1 | |
| SCHEMBL9804383 | 0.89 | CETP (0.41) | MAPK14FDFT1CETPFFAR1 | |
| SCHEMBL9804381 | 0.89 | CETP (0.41) | MAPK14FDFT1CETPFFAR1 | |
| SCHEMBL9804475 | 0.88 | MAPK14 (0.47) | PPARGPPARAMAPK14FDFT1CETP | |
| SCHEMBL9804470 | 0.88 | MAPK14 (0.47) | PPARGPPARAMAPK14FDFT1CETP | |
| SCHEMBL9804377 | 0.88 | PPARD (0.44) | MAPK14FDFT1CETPFFAR1 | |
| SCHEMBL9804369 | 0.88 | PPARD (0.44) | MAPK14FDFT1CETPFFAR1 | |
| SCHEMBL9804320 | 0.87 | KDM4E (0.48) | MAPK14LPAR1LPAR5CETPALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0240121-B1 | DIPHENYL ETHER DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-04-17 | — | — | EP | disclosed |
| EP-0390228-A2 | Chemical intermediates | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-10-03 | — | — | EP | disclosed |
| US-4791139-A | Diphenyl ether derivatives and their use as insecticides | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-12-13 | — | — | US | disclosed |
| EP-0240121-A2 | Diphenyl ether derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1987-10-07 | — | — | EP | disclosed |