Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR4 | O00206 | 1/20 | 0.34 |
| ▸ | TLR2 | O60603 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
| ▸ | EPOR | P19235 | 5/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CETP | P11597 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9804617 | 1.00 | TLR4 (0.34) | TLR4TLR2ALOX5PTGS1PTGS2 | |
| SCHEMBL9804643 | 0.84 | TLR4 (0.38) | TLR4TLR2ALOX5PTGS1PTGS2 | |
| SCHEMBL9804647 | 0.84 | TLR4 (0.38) | TLR4TLR2ALOX5PTGS1PTGS2 | |
| SCHEMBL9492708 | 0.76 | MAPK14 (0.42) | TLR4TLR2ALOX5PTGS1PTGS2 | |
| SCHEMBL9492710 | 0.76 | MAPK14 (0.42) | TLR4TLR2ALOX5PTGS1PTGS2 | |
| SCHEMBL9492691 | 0.72 | MAPK14 (0.41) | TLR4TLR2ALOX5PTGS1PTGS2 | |
| SCHEMBL9492684 | 0.72 | MAPK14 (0.41) | TLR4TLR2ALOX5PTGS1PTGS2 | |
| SCHEMBL9493701 | 0.69 | ALDH1A1 (0.38) | ALOX5MAPTNPC1RAB9ACETP | |
| SCHEMBL9493704 | 0.69 | ALDH1A1 (0.38) | ALOX5MAPTNPC1RAB9ACETP | |
| SCHEMBL10446782 | 0.69 | MEN1 (0.40) | TLR4TLR2ALOX5PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0240121-B1 | DIPHENYL ETHER DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-04-17 | — | — | EP | disclosed |
| EP-0390228-A2 | Chemical intermediates | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-10-03 | — | — | EP | disclosed |
| US-4791139-A | Diphenyl ether derivatives and their use as insecticides | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-12-13 | — | — | US | disclosed |
| EP-0240121-A2 | Diphenyl ether derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1987-10-07 | — | — | EP | disclosed |
| US-4690929-A | HYPOTENSIVE AGENTS | FARMITALIA CARLO ERBA (IT) | 1987-09-01 | — | — | US | disclosed |