Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR4 | O00206 | 1/20 | 0.38 |
| ▸ | TLR2 | O60603 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | EPOR | P19235 | 5/20 | 0.37 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9804647 | 1.00 | TLR4 (0.38) | TLR4TLR2ALOX5PTGS1PTGS2 | |
| SCHEMBL9492710 | 0.85 | MAPK14 (0.42) | TLR4TLR2ALOX5PTGS1PTGS2 | |
| SCHEMBL9492708 | 0.85 | MAPK14 (0.42) | TLR4TLR2ALOX5PTGS1PTGS2 | |
| SCHEMBL9804622 | 0.84 | TLR4 (0.34) | TLR4TLR2ALOX5PTGS1PTGS2 | |
| SCHEMBL9804617 | 0.84 | TLR4 (0.34) | TLR4TLR2ALOX5PTGS1PTGS2 | |
| SCHEMBL9492684 | 0.79 | MAPK14 (0.41) | TLR4TLR2ALOX5PTGS1PTGS2 | |
| SCHEMBL9492691 | 0.79 | MAPK14 (0.41) | TLR4TLR2ALOX5PTGS1PTGS2 | |
| SCHEMBL9493701 | 0.78 | ALDH1A1 (0.38) | ALOX5NPC1RAB9AMAPK14CETP | |
| SCHEMBL9493704 | 0.78 | ALDH1A1 (0.38) | ALOX5NPC1RAB9AMAPK14CETP | |
| SCHEMBL10446782 | 0.75 | MEN1 (0.40) | TLR4TLR2ALOX5PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0240121-B1 | DIPHENYL ETHER DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-04-17 | — | — | EP | disclosed |
| US-4791139-A | Diphenyl ether derivatives and their use as insecticides | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-12-13 | — | — | US | disclosed |