Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 4/20 | 0.34 |
| ▸ | CNR1 | P21554 | 3/20 | 0.34 |
| ▸ | HTR1B | P28222 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HTR1D | P28221 | 1/20 | 0.32 |
| ▸ | GBA1 | P04062 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | EBP | Q15125 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9804684 | 0.83 | EBP (0.33) | CNR2CNR1HTR1BALOX15HTR1D | |
| SCHEMBL11662606 | 0.80 | ADRA2A (0.43) | HTR1BALOX15HTR1DEBPSIGMAR1 | |
| SCHEMBL9804675 | 0.77 | CYP2C9 (0.39) | TLR7CNR2CNR1GBA1EBP | |
| SCHEMBL11469880 | 0.76 | POLB (0.43) | KDM4EL3MBTL1 | |
| SCHEMBL9804764 | 0.74 | KMT2A (0.40) | SMN1; SMN2KDM4E | |
| SCHEMBL9804851 | 0.74 | KDM4E (0.36) | SMN1; SMN2KDM4EL3MBTL1 | |
| SCHEMBL9804810 | 0.74 | CYP19A1 (0.39) | SMN1; SMN2KDM4EL3MBTL1EBPSIGMAR1 | |
| SCHEMBL9804889 | 0.70 | CYP1A2 (0.37) | TLR7KDM4EEBPSIGMAR1HRH1 | |
| SCHEMBL28039400 | 0.68 | HTR1B (0.39) | CNR2CNR1HTR1BSMN1; SMN2HTR1D | |
| SCHEMBL10371965 | 0.68 | CYP1A2 (0.39) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276920-B1 | (2-CYANO-2-(PHENYL OR NAPHTHYL)-2-SUBSTITUTED-ETHYL) PYRAZINES, PYRIMIDINES AND PYRIDAZINES | ROHM AND HAAS COMPANY (US) | 1991-04-03 | — | — | EP | disclosed |
| EP-0276920-A1 | (2-Cyano-2-(phenyl or naphthyl)-2-substituted-ethyl) pyrazines, pyrimidines and pyridazines | ROHM AND HAAS COMPANY (US) | 1988-08-03 | — | — | EP | disclosed |