Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 3/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28527124 | 0.87 | FPR2 (0.57) | FPR2CYP1A2CYP2C9CYP2C19NPSR1 | |
| SCHEMBL2970104 | 0.81 | FPR2 (0.51) | FPR2CYP1A2CYP2C9CYP2C19NPSR1 | |
| SCHEMBL28415000 | 0.78 | FPR2 (0.48) | FPR2CYP1A2CYP2C9CYP2C19NPSR1 | |
| SCHEMBL30554020 | 0.78 | FPR2 (0.48) | FPR2CYP1A2CYP2C9CYP2C19NPSR1 | |
| SCHEMBL28520005 | 0.77 | FPR2 (0.47) | FPR2CYP1A2CYP2C9CYP2C19NPSR1 | |
| SCHEMBL2407748 | 0.76 | LPO (0.44) | FPR2CYP1A2LMNAKDM4EALDH1A1 | |
| SCHEMBL14254645 | 0.76 | KCNH2 (0.35) | FPR2ALDH1A1POLBTSHRKMT2A | |
| SCHEMBL23706343 | 0.75 | FPR2 (0.41) | FPR2LMNAKDM4EMAPTPOLB | |
| SCHEMBL9806455 | 0.74 | FPR2 (0.37) | FPR2LMNAGAAKDM4ENPC1 | |
| SCHEMBL9806388 | 0.73 | SMN1; SMN2 (0.34) | FPR2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0299727-B1 | THERAPEUTIC AGENTS | Pfizer Limited (GB) | 1991-11-13 | — | — | EP | disclosed |
| US-4992447-A | Asthma | PFIZER INC. (US) | 1991-02-12 | — | — | US | disclosed |
| US-4853392-A | Fused 1,4-dihydropyridines as antiallergy and antiinflammatory agents | PFIZER INC. (US) | 1989-08-01 | — | — | US | disclosed |
| EP-0299727-A1 | Therapeutic agents | Pfizer Limited (GB) | 1989-01-18 | — | — | EP | disclosed |