Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 1/20 | 0.36 |
| ▸ | ALPG | P10696 | 2/20 | 0.35 |
| ▸ | PLAA | Q9Y263 | 1/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27867130 | 0.74 | KCNH2 (0.33) | SMN1; SMN2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14254645 | 0.73 | KCNH2 (0.35) | FPR2SMN1; SMN2PDE4APDE4BPDE4C | |
| SCHEMBL30487722 | 0.72 | FPR2 (0.36) | FPR2SLC6A3SLC6A2TDP1SLC6A4 | |
| SCHEMBL26196830 | 0.72 | KCNH2 (0.37) | SMN1; SMN2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9806401 | 0.72 | FPR2 (0.56) | FPR2SMN1; SMN2 | |
| SCHEMBL30487740 | 0.71 | FPR2 (0.35) | FPR2SLC6A3SLC6A2TDP1SLC6A4 | |
| SCHEMBL9806388 | 0.71 | SMN1; SMN2 (0.34) | FPR2SMN1; SMN2PDE4APDE4BPDE4C | |
| SCHEMBL18516668 | 0.71 | HSD17B10 (0.39) | SMN1; SMN2TDP1 | |
| SCHEMBL22005535 | 0.70 | SMN1; SMN2 (0.35) | SMN1; SMN2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14155877 | 0.70 | SMN1; SMN2 (0.43) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0299727-B1 | THERAPEUTIC AGENTS | Pfizer Limited (GB) | 1991-11-13 | — | — | EP | disclosed |
| US-4992447-A | Asthma | PFIZER INC. (US) | 1991-02-12 | — | — | US | disclosed |
| US-4853392-A | Fused 1,4-dihydropyridines as antiallergy and antiinflammatory agents | PFIZER INC. (US) | 1989-08-01 | — | — | US | disclosed |
| EP-0299727-A1 | Therapeutic agents | Pfizer Limited (GB) | 1989-01-18 | — | — | EP | disclosed |