Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.52 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | IGF1R | P08069 | 3/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | THRA | P10827 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | SGMS1 | Q86VZ5 | 1/20 | 0.47 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.47 |
| ▸ | RXRA | P19793 | 1/20 | 0.46 |
| ▸ | RXRB | P28702 | 1/20 | 0.46 |
| ▸ | RXRG | P48443 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27918636 | 0.95 | CYP1A2 (0.54) | ESR1ESR2MAPTRXFP1KAT8 | |
| SCHEMBL11218783 | 0.88 | THRA (0.57) | ESR1ESR2THRATHRB | |
| SCHEMBL68664 | 0.86 | ESR1 (0.68) | ESR1ESR2KAT8IGF1RALOX15 | |
| SCHEMBL31672999 | 0.84 | IGF1R (0.70) | MAPTRXFP1IGF1RALOX15HSD17B10 | |
| SCHEMBL17938812 | 0.84 | IGF1R (0.70) | MAPTRXFP1IGF1RALOX15HSD17B10 | |
| SCHEMBL6227927 | 0.84 | ESR1 (0.65) | ESR1ESR2KAT8IGF1RALOX15 | |
| SCHEMBL8402779 | 0.84 | ESR1 (0.65) | ESR1ESR2KAT8IGF1RALOX15 | |
| SCHEMBL16065724 | 0.84 | ESR1 (0.65) | ESR1ESR2KAT8IGF1RALOX15 | |
| SCHEMBL12949979 | 0.84 | ESR1 (0.65) | ESR1ESR2KAT8IGF1RALOX15 | |
| SCHEMBL10826793 | 0.83 | IGF1R (0.68) | MAPTRXFP1IGF1RALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1875002-B | Phenyl derivatives as PPAR agonists | HOFFMANN LA ROCHE | 2011-08-03 | — | — | CN | disclosed |
| CN-1875002-A | Phenyl derivatives as PPAR agonists | HOFFMANN LA ROCHE (CH) | 2006-12-06 | — | — | CN | disclosed |
| US-5064914-A | By transesterification; high melt strength; extrusion, blow molding | GENERAL ELECTRIC COMPANY (US) | 1991-11-12 | — | — | US | disclosed |