Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 12/20 | 0.83 |
| ▸ | AKR1A1 | P14550 | 10/20 | 0.83 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.73 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.48 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | SCN1A | P35498 | 1/20 | 0.45 |
| ▸ | SCN4A | P35499 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.45 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10930167 | 0.91 | AKR1A1 (1.00) | AKR1B1AKR1A1ITGA4PDK2CRHBP | |
| SCHEMBL31195728 | 0.85 | ITGA4 (1.00) | AKR1B1AKR1A1ITGA4CRHBPCRHR2 | |
| SCHEMBL9810959 | 0.85 | ITGA4 (1.00) | AKR1B1AKR1A1ITGA4CRHBPCRHR2 | |
| SCHEMBL11001789 | 0.82 | AKR1B1 (1.00) | AKR1B1AKR1A1ITGA4 | |
| SCHEMBL25892679 | 0.82 | ITGA4 (0.73) | AKR1B1AKR1A1ITGA4PDK2CRHBP | |
| SCHEMBL9810968 | 0.82 | ITGA4 (0.73) | AKR1B1AKR1A1ITGA4PDK2 | |
| SCHEMBL21095655 | 0.82 | ITGA4 (0.73) | AKR1B1AKR1A1ITGA4PDK2CRHBP | |
| SCHEMBL25893157 | 0.79 | ITGA4 (0.69) | AKR1B1AKR1A1ITGA4CRHBPCRHR2 | |
| SCHEMBL9811052 | 0.79 | ITGA4 (0.73) | AKR1B1AKR1A1ITGA4PDK2CRHBP | |
| SCHEMBL22380690 | 0.78 | AKR1B1 (0.73) | AKR1B1AKR1A1ITGA4PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0092385-B1 | HYDANTOIN DERIVATIVES FOR USE IN INHIBITING ALDOSE REDUCTASE ACTIVITY, COMPOSITIONS THEREFOR AND PROCESS FOR PREPARING SPIRO-FLUOREN COMPOUNDS | ALCON LABORATORIES, INC. (US) | 1991-06-12 | — | — | EP | disclosed |
| US-4540700-A | Treatment of diabetic complications with certain spiro-imidazolidine-diones | ALCON LABORATORIES, INC. (US) | 1985-09-10 | — | — | US | disclosed |
| US-4436745-A | TETRACYCLIC SPIROHYDANTOINS | ALCON LABORATORIES, INC. (US) | 1984-03-13 | — | — | US | disclosed |