Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 0.52 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.43 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8608503 | 0.94 | AKR1C1 (0.47) | AKT1AKR1C1ALDH1A1MAPTLMNA | |
| SCHEMBL1304548 | 0.94 | AKR1C1 (0.47) | AKT1AKR1C1ALDH1A1MAPTLMNA | |
| SCHEMBL8829794 | 0.92 | AKR1C1 (0.45) | AKT1AKR1C1ALDH1A1MAPTLMNA | |
| SCHEMBL5586432 | 0.81 | CYP19A1 (0.61) | AKT1AKR1C1ALDH1A1MAPTLMNA | |
| SCHEMBL27775387 | 0.81 | CYP19A1 (0.52) | AKR1C1ALDH1A1MAPTLMNAMEN1 | |
| SCHEMBL4817483 | 0.78 | HDAC3 (0.54) | AKR1C1ALDH1A1MAPTLMNAPOLB | |
| SCHEMBL7995907 | 0.77 | ALDH1A1 (0.54) | AKR1C1ALDH1A1MAPTLMNAPOLB | |
| SCHEMBL566814 | 0.77 | ALDH1A1 (0.54) | AKR1C1ALDH1A1MAPTLMNAPOLB | |
| SCHEMBL566813 | 0.77 | ALDH1A1 (0.54) | AKR1C1ALDH1A1MAPTLMNAPOLB | |
| SCHEMBL14970312 | 0.77 | ALDH1A1 (0.56) | ALDH1A1MAPTLMNAMEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1892789-B1 | LITHIUM SECONDARY BATTERY | MITSUBISHI CHEM CORP (JP) | 2018-02-28 | — | — | EP | disclosed |
| US-20110014504-A1 | LITHIUM SECONDARY BATTERY | MITSUBISHI CHEMICAL CORPORATION (JP) | 2011-01-20 | — | — | US | disclosed |
| US-20080311478-A1 | Lithium Secondary Battery | MITSUBISHI CHEMICAL CORPORATION (JP) | 2008-12-18 | — | — | US | disclosed |
| EP-1892789-A1 | LITHIUM SECONDARY BATTERY | Mitsubishi Chemical Corporation (JP) | 2008-02-27 | — | — | EP | disclosed |