Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 9/20 | 0.67 |
| ▸ | ADRB3 | P13945 | 8/20 | 0.67 |
| ▸ | ADRB1 | P08588 | 7/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.57 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.57 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9812017 | 1.00 | ADRB2 (0.67) | ADRB2ADRB3ADRB1CYP2D6ADRA1D | |
| SCHEMBL9812023 | 1.00 | ADRB2 (0.67) | ADRB2ADRB3ADRB1CYP2D6ADRA1D | |
| SCHEMBL11253857 | 0.92 | ADRB3 (0.77) | ADRB2ADRB3ADRB1CYP2D6ADRA1D | |
| SCHEMBL7153653 | 0.88 | ADRB2 (0.62) | ADRB2ADRB3ADRB1CYP2D6ADRA1D | |
| SCHEMBL7153650 | 0.88 | ADRB2 (0.62) | ADRB2ADRB3ADRB1CYP2D6ADRA1D | |
| SCHEMBL9812002 | 0.87 | ADRB3 (0.55) | ADRB2ADRB3ADRB1CYP2D6ADRA1D | |
| SCHEMBL9812090 | 0.87 | ADRB2 (0.60) | ADRB2ADRB3ADRB1CYP2D6ADRA1D | |
| SCHEMBL9631224 | 0.85 | LTA4H (0.55) | ADRB2ADRB3ADRB1CYP2D6ADRA1D | |
| SCHEMBL9631236 | 0.85 | LTA4H (0.55) | ADRB2ADRB3ADRB1CYP2D6ADRA1D | |
| SCHEMBL9812015 | 0.85 | ADRB3 (0.50) | ADRB2ADRB3ADRB1CYP2D6ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0170121-B1 | 2-HYDROXY-3-ARYLOXYPROPYL OR 2-HYDROXY-2-BENZOFURANYL ETHYL TERTIARY AMINE HAVING AN ANTI-HYPERGLYCAEMIC AND/OR ANTI-OBESITY ACTIVITY | BEECHAM GROUP PLC (GB) | 1991-06-19 | — | — | EP | disclosed |
| EP-0170121-A1 | 2-Hydroxy-3-aryloxypropyl or 2-hydroxy-2-benzofuranyl ethyl tertiary amine having an anti-hyperglycaemic and/or anti-obesity activity | BEECHAM GROUP PLC (GB) | 1986-02-05 | — | — | EP | disclosed |