Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 6/20 | 0.61 |
| ▸ | PDE4A | P27815 | 5/20 | 0.61 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.61 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9656953 | 0.87 | PDE4B (0.69) | PDE4BPDE4APDE4CPDE4DKDM4E | |
| SCHEMBL5382294 | 0.82 | MAPT (0.53) | PDE4BPDE4APDE4CPDE4DKDM4E | |
| SCHEMBL13372165 | 0.80 | KDM4E (0.58) | PDE4BPDE4APDE4CPDE4DKDM4E | |
| SCHEMBL29535843 | 0.79 | ALDH1A1 (0.56) | PDE4BPDE4APDE4CPDE4DKDM4E | |
| SCHEMBL283173 | 0.79 | ALDH1A1 (0.56) | PDE4BPDE4APDE4CPDE4DKDM4E | |
| SCHEMBL18950744 | 0.78 | KDM4E (0.75) | PDE4BPDE4APDE4CPDE4DKDM4E | |
| SCHEMBL9812673 | 0.77 | PDE4B (0.51) | PDE4BPDE4APDE4CPDE4DKDM4E | |
| SCHEMBL1128021 | 0.76 | KDM4E (0.64) | PDE4BPDE4APDE4CPDE4DKDM4E | |
| SCHEMBL28783170 | 0.76 | MAPT (0.53) | PDE4BPDE4APDE4CPDE4DKDM4E | |
| SCHEMBL9448813 | 0.75 | KDM4E (0.62) | PDE4BPDE4APDE4CPDE4DKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0146348-B1 | SUBSTITUTED NAPHTHALENES, INDOLES, BENZOFURANS AND BENZOTHIOPHENES AS LIPOXYGENASE INHIBITORS | THE UPJOHN COMPANY (US) | 1991-07-31 | — | — | EP | claimed |
| US-4737519-A | Substituted naphthalenes, indoles, benzofurans, and benzothiophenes as lipoxygenase inhibitors | THE UPJOHN COMPANY (US) | 1988-04-12 | — | — | US | claimed |
| EP-0146348-A2 | Substituted naphthalenes, indoles, benzofurans and benzothiophenes as lipoxygenase inhibitors | THE UPJOHN COMPANY (US) | 1985-06-26 | — | — | EP | claimed |
| US-7226661-B2 | Synthesis of quinones and phenols on solid support | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2007-06-05 | — | — | US | disclosed |
| EP-0146348-B1 | SUBSTITUTED NAPHTHALENES, INDOLES, BENZOFURANS AND BENZOTHIOPHENES AS LIPOXYGENASE INHIBITORS | THE UPJOHN COMPANY (US) | 1991-07-31 | — | — | EP | disclosed |
| WO-1990003374-A1 | 1,4-DIHYDROTHIONAPTHOQUINONE AND HETEROCYCLIC CONGENERS WHICH INHIBIT LIPOXYGENASE ENZYMES | THE UPJOHN COMPANY (US) | 1990-04-05 | — | — | WO | disclosed |
| US-4737519-A | Substituted naphthalenes, indoles, benzofurans, and benzothiophenes as lipoxygenase inhibitors | THE UPJOHN COMPANY (US) | 1988-04-12 | — | — | US | disclosed |
| EP-0146348-A2 | Substituted naphthalenes, indoles, benzofurans and benzothiophenes as lipoxygenase inhibitors | THE UPJOHN COMPANY (US) | 1985-06-26 | — | — | EP | disclosed |