Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 6/20 | 0.51 |
| ▸ | PDE4A | P27815 | 5/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.33 |
| ▸ | TUBB | P07437 | 1/20 | 0.33 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.33 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.33 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.33 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9812619 | 0.77 | PDE4B (0.61) | PDE4BPDE4APDE4CPDE4DLMNA | |
| SCHEMBL9656953 | 0.72 | PDE4B (0.69) | PDE4BPDE4APDE4CPDE4DLMNA | |
| SCHEMBL9812668 | 0.71 | CTSV (0.32) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL29244761 | 0.66 | PDE4B (0.78) | PDE4BPDE4APDE4CPDE4DKDM4E | |
| SCHEMBL5382294 | 0.66 | MAPT (0.53) | PDE4BPDE4APDE4CPDE4DLMNA | |
| SCHEMBL12181771 | 0.66 | PDE4B (0.71) | PDE4BPDE4APDE4CPDE4DLMNA | |
| SCHEMBL11776875 | 0.65 | PDE4B (0.64) | PDE4BPDE4APDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL27980917 | 0.64 | PDE4B (0.67) | PDE4BPDE4APDE4CPDE4DLMNA | |
| SCHEMBL22081628 | 0.63 | PDE4B (0.55) | PDE4BPDE4APDE4CPDE4DLMNA | |
| SCHEMBL21384700 | 0.63 | PDE4B (0.55) | PDE4BPDE4APDE4CPDE4DLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0146348-B1 | SUBSTITUTED NAPHTHALENES, INDOLES, BENZOFURANS AND BENZOTHIOPHENES AS LIPOXYGENASE INHIBITORS | THE UPJOHN COMPANY (US) | 1991-07-31 | — | — | EP | claimed |
| EP-0146348-A2 | Substituted naphthalenes, indoles, benzofurans and benzothiophenes as lipoxygenase inhibitors | THE UPJOHN COMPANY (US) | 1985-06-26 | — | — | EP | claimed |
| EP-0146348-B1 | SUBSTITUTED NAPHTHALENES, INDOLES, BENZOFURANS AND BENZOTHIOPHENES AS LIPOXYGENASE INHIBITORS | THE UPJOHN COMPANY (US) | 1991-07-31 | — | — | EP | disclosed |
| US-4737519-A | Substituted naphthalenes, indoles, benzofurans, and benzothiophenes as lipoxygenase inhibitors | THE UPJOHN COMPANY (US) | 1988-04-12 | — | — | US | disclosed |
| EP-0146348-A2 | Substituted naphthalenes, indoles, benzofurans and benzothiophenes as lipoxygenase inhibitors | THE UPJOHN COMPANY (US) | 1985-06-26 | — | — | EP | disclosed |