Coumaphos

Coumaphos

SCHEMBL9812699

CCOP(=S)(OCC)Oc1ccc2c(C)c(Cl)c(=O)oc2c1.OP(O)(O)=S

nearest known ligand 0.93

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 8/20 0.93
ALDH1A1 P00352 8/20 0.93
HPGD P15428 6/20 0.93
TDP1 Q9NUW8 2/20 0.93
CA12 O43570 2/20 0.93
CA1 P00915 2/20 0.93
CA4 P22748 2/20 0.93
CA5A P35218 2/20 0.93
CA7 P43166 2/20 0.93
CA5B Q9Y2D0 2/20 0.93
CA3 P07451 1/20 0.93
CYP3A4 P08684 1/20 0.93
CA6 P23280 1/20 0.93
CA9 Q16790 1/20 0.93
CA13 Q8N1Q1 1/20 0.93
CA14 Q9ULX7 1/20 0.93
GAA P10253 4/20 0.63
HSD17B10 Q99714 2/20 0.61
USP2 O75604 1/20 0.61
GLA P06280 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Coumaphos SCHEMBL9283960 0.97 KDM4E (1.00) KDM4EALDH1A1HPGDTDP1CA12
Coumaphos SCHEMBL29363459 0.97 KDM4E (1.00) KDM4EALDH1A1HPGDTDP1CA12
Coumaphos SCHEMBL120173 0.97 KDM4E (1.00) KDM4EALDH1A1HPGDTDP1CA12
Coumaphos SCHEMBL9812694 0.96 KDM4E (0.89) KDM4EALDH1A1HPGDTDP1CA12
Coumaphos SCHEMBL3750396 0.89 KDM4E (0.86) KDM4EALDH1A1HPGDTDP1CA12
Coumaphos SCHEMBL16446216 0.87 KDM4E (0.81) KDM4EALDH1A1HPGDTDP1CA12
Coumaphos SCHEMBL27835983 0.86 KDM4E (0.79) KDM4EALDH1A1HPGDTDP1CA12
SCHEMBL4104048 0.85 KDM4E (0.70) KDM4EALDH1A1HPGDTDP1CA12
SCHEMBL38663564 0.85 KDM4E (0.70) KDM4EALDH1A1HPGDTDP1CA12
SCHEMBL669657 0.84 KDM4E (0.77) KDM4EALDH1A1HPGDTDP1CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0273862-B1 NON-AQUEOUS LIQUID ECTOPARASITICIDAL POUR-ON FORMULATION CIBA-GEIGY AG (CH) 1991-07-10 EP claimed