Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.70 |
| ▸ | HPGD | P15428 | 6/20 | 0.70 |
| ▸ | CA12 | O43570 | 1/20 | 0.70 |
| ▸ | CA1 | P00915 | 1/20 | 0.70 |
| ▸ | CA3 | P07451 | 1/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.70 |
| ▸ | CA4 | P22748 | 1/20 | 0.70 |
| ▸ | CA6 | P23280 | 1/20 | 0.70 |
| ▸ | CA5A | P35218 | 1/20 | 0.70 |
| ▸ | CA7 | P43166 | 1/20 | 0.70 |
| ▸ | CA9 | Q16790 | 1/20 | 0.70 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.70 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.70 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.70 |
| ▸ | GAA | P10253 | 4/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.67 |
| ▸ | USP2 | O75604 | 1/20 | 0.64 |
| ▸ | GLA | P06280 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38663564 | 1.00 | KDM4E (0.70) | KDM4EALDH1A1HPGDCA12CA1 | |
| SCHEMBL4104045 | 0.86 | KDM4E (0.65) | KDM4EALDH1A1HPGDCA12CA1 | |
| Coumaphos SCHEMBL9812699 | 0.85 | KDM4E (0.93) | KDM4EALDH1A1HPGDCA12CA1 | |
| Coumaphos SCHEMBL9812694 | 0.83 | KDM4E (0.89) | KDM4EALDH1A1HPGDCA12CA1 | |
| Coumaphos SCHEMBL9283960 | 0.83 | KDM4E (1.00) | KDM4EALDH1A1HPGDCA12CA1 | |
| Coumaphos SCHEMBL120173 | 0.83 | KDM4E (1.00) | KDM4EALDH1A1HPGDCA12CA1 | |
| Coumaphos SCHEMBL29363459 | 0.83 | KDM4E (1.00) | KDM4EALDH1A1HPGDCA12CA1 | |
| SCHEMBL18284647 | 0.82 | KDM4E (0.76) | KDM4EALDH1A1HPGDCA12CA1 | |
| SCHEMBL23743853 | 0.81 | KDM4E (0.74) | KDM4EALDH1A1HPGDCA12CA1 | |
| SCHEMBL3265953 | 0.81 | KDM4E (0.62) | KDM4EALDH1A1HPGDCA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11254701-B2 | Spinosyn formulations for treatment of Demodex-induced ocular and facial conditions | APERTA BIOSCIENCES, LLC (US) | 2022-02-22 | — | — | US | disclosed |
| CN-112770742-A | Spinosad formulations for the treatment of demodex-induced eye and face diseases | 阿佩塔生物科学有限公司 | 2021-05-07 | — | — | CN | disclosed |
| US-10730901-B2 | Spinosyn formulations for treatment of demodex-induced ocular and facial conditions | APERTA BIOSCIENCES, LLC (US) | 2020-08-04 | — | — | US | disclosed |
| US-20200031859-A1 | SPINOSYN FORMULATIONS FOR TREATMENT OF DEMODEX-INDUCED OCULAR AND FACIAL CONDITIONS | APERTA BIOSCIENCES, LLC | 2020-01-30 | — | — | US | disclosed |
| US-9493805-B2 | Enzymatic biosensors with enhanced activity retention for detection of organic compounds | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2016-11-15 | — | — | US | disclosed |
| US-20130143844-A1 | ECTOPARASITICIDE-CONTAINING PREPARATION FOR SPONTANEOUS EMULSION FORMATION | BAYER ANIMAL HELATH GMBH (DE) | 2013-06-06 | — | — | US | disclosed |
| US-8323956-B2 | Distal tip of biosensor transducer comprising enzyme for deamination | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2012-12-04 | — | — | US | disclosed |
| US-20090221014-A1 | Enzymatic Biosensors With Enhanced Activity Retention For Detection Of Organic Compounds | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION | 2009-09-03 | — | — | US | disclosed |
| US-20090026092-A1 | Enzymatic Biosensors With Enhanced Activity Retention For Detection Of Organic Compounds | NIH - DEITR | 2009-01-29 | — | — | US | disclosed |
| US-20050214336-A1 | Parasite control in animals | BAYER HEALTHCARE AG (DE) | 2005-09-29 | — | — | US | disclosed |
| US-4678777-A | SYNERGISTS | BAYER AKTIENGESELLSCHAFT (DE) | 1987-07-07 | — | — | US | disclosed |
| US-4609648-A | SYNERGISTS FOR ARTHROPODICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1986-09-02 | — | — | US | disclosed |
| US-4575516-A | SYNERGISTS | BAYER AKTIENGESELLSCHAFT (DE) | 1986-03-11 | — | — | US | disclosed |
| EP-0144721-A1 | Agent for the control of varoatose | BAYER AG (DE) | 1985-06-19 | — | — | EP | disclosed |
| US-4511562-A | (Thio)(dithio-phosphates(phosphonates), processes for their preparation, and their use in pest-combating agents | BAYER AKTIENGESELLSCHAFT (DE) | 1985-04-16 | — | — | US | disclosed |
| US-4500348-A | Oil-in-water emulsions, and their use | BAYER AKTIENGESELLSCHAFT (DE) | 1985-02-19 | — | — | US | disclosed |
| US-4330674-A | INSECTICIDES, NEMATOCIDES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1982-05-18 | — | — | US | disclosed |
| US-4309425-A | Miticidal, insecticidal, ovicidal and fungicidal N-(N',N'-diarylaminothio)sulfonamides | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1982-01-05 | — | — | US | disclosed |
| US-4254141-A | INSECTICIDES, MITICIDES, NEMATOCIDES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1981-03-03 | — | — | US | disclosed |
| US-4056631-A | CARBODIMINES, MITICIDE | SHOWA DENKO K.K. (JA) | 1977-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200031859-A1 | SPINOSYN FORMULATIONS FOR TREATMENT OF DEMODEX-INDUCED OCULAR AND FACIAL CONDITIONS | SOST, KRT18, DSTN | KDM4E 3025/4885ALDH1A1 4200/4885HPGD 4332/4885 |
| US-10730901-B2 | Spinosyn formulations for treatment of demodex-induced ocular and facial conditions | SOST, KRT18, DSTN | KDM4E 3025/4885ALDH1A1 4200/4885HPGD 4332/4885 |
| US-20130143844-A1 | ECTOPARASITICIDE-CONTAINING PREPARATION FOR SPONTANEOUS EMULSION FORMATION | LIPA, PHOSPHO1, NAPEPLD | KDM4E 4266/4885ALDH1A1 3856/4885HPGD 2702/4885 |
| US-11254701-B2 | Spinosyn formulations for treatment of Demodex-induced ocular and facial conditions | SOST, KRT18, DSTN | KDM4E 3025/4885ALDH1A1 4200/4885HPGD 4332/4885 |
| US-20050214336-A1 | Parasite control in animals | PKLR, PKM, TKT | KDM4E 89/4885ALDH1A1 857/4885HPGD 1577/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.