Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27496475 | 0.90 | KMT2A (0.53) | POLBKMT2AMEN1ESR1ESR2 | |
| SCHEMBL10832377 | 0.87 | ESR1 (0.48) | POLBKMT2AMEN1ESR1ESR2 | |
| SCHEMBL10832633 | 0.86 | L3MBTL1 (0.50) | POLBKMT2AMEN1ESR1ESR2 | |
| SCHEMBL22394854 | 0.85 | ESR1 (0.63) | POLBKMT2ACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL3264863 | 0.84 | ESR1 (0.50) | KMT2ACYP2D6MEN1ESR1ESR2 | |
| SCHEMBL10452447 | 0.83 | POLB (0.49) | POLBKMT2ACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL28596422 | 0.80 | KMT2A (0.43) | KMT2ACYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL8841184 | 0.79 | TSHR (0.48) | POLBKMT2AMEN1CA12CA7 | |
| SCHEMBL10832866 | 0.78 | L3MBTL1 (0.56) | POLBKMT2ACYP2D6CYP2C9CYP2C19 | |
| SCHEMBL10833308 | 0.78 | ESR1 (0.53) | POLBKMT2AESR1ESR2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0244077-B1 | SULPHIDES DERIVED FROM SUBSTITUTED PHENYL-2-ACRYLIC ACID | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-07-24 | — | — | EP | disclosed |
| EP-0244077-A1 | Sulphides derived from substituted phenyl-2-acrylic acid | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1987-11-04 | — | — | EP | disclosed |