Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | PPARG | P37231 | 4/20 | 0.52 |
| ▸ | PPARA | Q07869 | 4/20 | 0.52 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | EPOR | P19235 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.43 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9813018 | 1.00 | LMNA (0.53) | LMNAPPARGPPARAACMSDKDM4E | |
| SCHEMBL3175679 | 0.87 | LMNA (0.54) | LMNAPPARGPPARAACMSDKDM4E | |
| SCHEMBL3175689 | 0.87 | LMNA (0.54) | LMNAPPARGPPARAACMSDKDM4E | |
| SCHEMBL3165159 | 0.85 | LMNA (0.53) | LMNAPPARGPPARAACMSDKDM4E | |
| SCHEMBL3165146 | 0.85 | LMNA (0.53) | LMNAPPARGPPARAACMSDKDM4E | |
| SCHEMBL4683421 | 0.85 | LMNA (0.53) | LMNAPPARGPPARAACMSDKDM4E | |
| SCHEMBL14143474 | 0.85 | KDM4E (0.57) | LMNAPPARGPPARAACMSDKDM4E | |
| SCHEMBL4683425 | 0.85 | LMNA (0.53) | LMNAPPARGPPARAACMSDKDM4E | |
| SCHEMBL4683688 | 0.81 | CCNB2 (0.65) | LMNAPPARGPPARAACMSDKDM4E | |
| SCHEMBL4683690 | 0.81 | CCNB2 (0.65) | LMNAPPARGPPARAACMSDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0223593-B1 | PHENOXYALKYLCARBOXYLIC ACIDS AND ESTERS AND THEIR PREPARATION AND PHARMACEUTICAL FORMULATION | GLAXO GROUP LIMITED (GB) | 1991-08-07 | — | — | EP | disclosed |
| EP-0223593-A2 | Phenoxyalkylcarboxylic acids and esters and their preparation and pharmaceutical formulation | GLAXO GROUP LIMITED (GB) | 1987-05-27 | — | — | EP | disclosed |