Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.41 |
| ▸ | SNCA | P37840 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.31 |
| ▸ | CDK2 | P24941 | 2/20 | 0.31 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9813210 | 0.87 | MAPT (0.41) | NOX1SNCAMEN1LMNAGAA | |
| SCHEMBL2987616 | 0.87 | SNCA (0.50) | NOX1SNCAMEN1LMNAGAA | |
| SCHEMBL10575740 | 0.75 | MEN1 (0.45) | NOX1SNCAMEN1LMNAGAA | |
| SCHEMBL10591899 | 0.75 | NOX1 (0.43) | NOX1SNCAMEN1LMNAGAA | |
| SCHEMBL10569969 | 0.73 | SNCA (0.50) | NOX1SNCAMEN1LMNAGAA | |
| SCHEMBL10591790 | 0.71 | NOX1 (0.44) | NOX1GAAMAPTMAPK1 | |
| SCHEMBL10590538 | 0.69 | MEN1 (0.40) | NOX1SNCAMEN1LMNAGAA | |
| SCHEMBL10590992 | 0.69 | MAPT (0.44) | NOX1SNCAMEN1LMNAGAA | |
| SCHEMBL10592334 | 0.68 | SNCA (0.41) | NOX1SNCAMEN1LMNAGAA | |
| SCHEMBL10593192 | 0.67 | L3MBTL1 (0.43) | NOX1SNCAMEN1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0138481-B1 | LEUKOTRIENE BIOSYNTHESIS INHIBITORS | MERCK FROSST CANADA INC. (CA) | 1991-06-26 | — | — | EP | disclosed |
| US-4845083-A | PHENOTHIAZINE DERIVATIVES AND ANALOGS | MERCK FROSST CANADA, INC. (CA) | 1989-07-04 | — | — | US | disclosed |
| EP-0138481-A2 | Leukotriene biosynthesis inhibitors | MERCK FROSST CANADA INC. (CA) | 1985-04-24 | — | — | EP | disclosed |