Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNFSF11 | O14788 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | JUN | P05412 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.38 |
| ▸ | TUBB | P07437 | 1/20 | 0.38 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.38 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.38 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.38 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.38 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.38 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.38 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.38 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.38 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.38 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.38 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.38 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.38 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9813221 | 0.79 | TUBB4A (0.41) | BACE1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL9813149 | 0.76 | SNCA (0.61) | TNFSF11BACE1TSHRTUBB4ATUBB | |
| SCHEMBL9813220 | 0.75 | KMT2A (0.58) | TNFSF11BACE1TSHRTUBB4ATUBB | |
| SCHEMBL3328971 | 0.71 | TSHR (0.64) | TNFSF11BACE1TSHRJUNNFKB1 | |
| SCHEMBL3327344 | 0.71 | CA12 (0.63) | TNFSF11BACE1TSHRTUBB4ATUBB | |
| SCHEMBL11793587 | 0.70 | BACE1 (0.61) | TNFSF11BACE1TSHRJUNNFKB1 | |
| SCHEMBL20551035 | 0.68 | NOX1 (0.50) | MEN1KMT2AALDH1A1MAPTL3MBTL1 | |
| SCHEMBL21723164 | 0.67 | TNFSF11 (0.83) | TNFSF11BACE1TSHRJUNNFKB1 | |
| SCHEMBL27602532 | 0.67 | TNFSF11 (0.83) | TNFSF11BACE1TSHRJUNNFKB1 | |
| SCHEMBL8928654 | 0.67 | TNFSF11 (0.83) | TNFSF11BACE1TSHRJUNNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0138481-B1 | LEUKOTRIENE BIOSYNTHESIS INHIBITORS | MERCK FROSST CANADA INC. (CA) | 1991-06-26 | — | — | EP | disclosed |
| US-4845083-A | PHENOTHIAZINE DERIVATIVES AND ANALOGS | MERCK FROSST CANADA, INC. (CA) | 1989-07-04 | — | — | US | disclosed |
| EP-0138481-A2 | Leukotriene biosynthesis inhibitors | MERCK FROSST CANADA INC. (CA) | 1985-04-24 | — | — | EP | disclosed |