Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 3/20 | 0.61 |
| ▸ | NOX1 | Q9Y5S8 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | TNFSF11 | O14788 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10500347 | 0.80 | NOX1 (0.52) | SNCANOX1MEN1KMT2AMAPT | |
| SCHEMBL9813306 | 0.80 | SNCA (0.71) | SNCANOX1MEN1KMT2AMAPT | |
| SCHEMBL9813175 | 0.79 | SNCA (0.50) | SNCANOX1MEN1KMT2AMAPT | |
| SCHEMBL29636455 | 0.78 | SNCA (1.00) | SNCANOX1MEN1KMT2AMAPT | |
| SCHEMBL3489840 | 0.78 | SNCA (1.00) | SNCANOX1MEN1KMT2AMAPT | |
| SCHEMBL2609258 | 0.77 | NOX1 (0.66) | SNCANOX1MEN1KMT2AMAPT | |
| SCHEMBL9813193 | 0.76 | TNFSF11 (0.42) | SNCAMEN1KMT2AMAPTL3MBTL1 | |
| SCHEMBL9813220 | 0.76 | KMT2A (0.58) | MEN1KMT2AMAPTL3MBTL1HTT | |
| SCHEMBL28383858 | 0.75 | SNCA (0.53) | SNCANOX1MEN1KMT2AMAPT | |
| SCHEMBL31425266 | 0.73 | SNCA (0.63) | SNCANOX1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0138481-B1 | LEUKOTRIENE BIOSYNTHESIS INHIBITORS | MERCK FROSST CANADA INC. (CA) | 1991-06-26 | — | — | EP | disclosed |
| US-4845083-A | PHENOTHIAZINE DERIVATIVES AND ANALOGS | MERCK FROSST CANADA, INC. (CA) | 1989-07-04 | — | — | US | disclosed |
| EP-0138481-A2 | Leukotriene biosynthesis inhibitors | MERCK FROSST CANADA INC. (CA) | 1985-04-24 | — | — | EP | disclosed |