Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MMP1 | P03956 | 3/20 | 0.44 |
| ▸ | MMP2 | P08253 | 3/20 | 0.44 |
| ▸ | MMP9 | P14780 | 3/20 | 0.44 |
| ▸ | MAOB | P27338 | 3/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9813543 | 1.00 | ALDH1A1 (0.56) | ALDH1A1TDP1MEN1KMT2AMAPT | |
| SCHEMBL9813604 | 0.85 | ALDH1A1 (0.57) | ALDH1A1TDP1MEN1KMT2AMAPT | |
| SCHEMBL9813602 | 0.85 | ALDH1A1 (0.57) | ALDH1A1TDP1MEN1KMT2AMAPT | |
| SCHEMBL9813589 | 0.85 | ALDH1A1 (0.66) | ALDH1A1TDP1MEN1KMT2AMAPT | |
| SCHEMBL9813586 | 0.85 | ALDH1A1 (0.66) | ALDH1A1TDP1MEN1KMT2AMAPT | |
| SCHEMBL9813551 | 0.81 | ALDH1A1 (0.59) | ALDH1A1TDP1MEN1KMT2AMAPT | |
| SCHEMBL9813552 | 0.81 | ALDH1A1 (0.59) | ALDH1A1TDP1MEN1KMT2AMAPT | |
| SCHEMBL9813546 | 0.78 | ALDH1A1 (0.71) | ALDH1A1TDP1MAPTPSMD14MMP1 | |
| SCHEMBL9813545 | 0.78 | ALDH1A1 (0.71) | ALDH1A1TDP1MAPTPSMD14MMP1 | |
| Ralitoline SCHEMBL635346 | 0.78 | PSMD14 (0.55) | ALDH1A1TDP1PSMD14MAOBEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0124911-B1 | 4-OXO-THIAZOLIDIN-2-YLIDEN-ACETAMIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND MEDICAMENTS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM ILLNESSES CONTAINING THEM | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1991-07-31 | — | — | EP | disclosed |
| US-4563471-A | CENTRAL NERVOUS SYSTEM DISORDERS | WARNER-LAMBERT COMPANY (US) | 1986-01-07 | — | — | US | disclosed |
| EP-0124911-A2 | 4-Oxo-thiazolidin-2-yliden-acetamide derivatives, process for their preparation, and medicaments for the treatment of central nervous system illnesses containing them | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1984-11-14 | — | — | EP | disclosed |