Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 5/20 | 0.43 |
| ▸ | MTOR | P42345 | 3/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.43 |
| ▸ | ATR | Q13535 | 2/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 3/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.39 |
| ▸ | MERTK | Q12866 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL98137 | 0.87 | ALDH1A1 (0.49) | PIK3CAMTORPIK3CGATRNOS1 | |
| SCHEMBL99029 | 0.78 | ALDH1A1 (0.49) | PIK3CAMTORPIK3CGNOS1CNR2 | |
| SCHEMBL30440406 | 0.74 | PIK3CA (0.52) | PIK3CAMTORPIK3CGATRCNR2 | |
| SCHEMBL336380 | 0.74 | PIK3CA (0.52) | PIK3CAMTORPIK3CGATRCNR2 | |
| SCHEMBL98344 | 0.73 | ALDH1A1 (0.49) | PIK3CANOS1CNR2PDE10ATLR9 | |
| SCHEMBL100676 | 0.73 | ALDH1A1 (0.49) | PIK3CANOS1CNR2PDE10ATLR9 | |
| SCHEMBL98831 | 0.72 | PDE10A (0.41) | PIK3CAATRNOS1PDE10AMERTK | |
| SCHEMBL99742 | 0.71 | PIK3CA (0.37) | PIK3CANOS1CNR2PDE10ATLR9 | |
| SCHEMBL98381 | 0.71 | ALDH1A1 (0.54) | PIK3CANOS1PDE10ATLR9TLR7 | |
| SCHEMBL336204 | 0.71 | PIK3CA (0.67) | PIK3CAMTORPIK3CGHDAC1PIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2426130-B1 | PURINE DERIVATIVE AND ANTITUMOR AGENT USING SAME | ZENYAKU KOGYO KK (JP) | 2015-03-11 | — | — | EP | disclosed |
| EP-2426130-A1 | PURINE DERIVATIVE AND ANTITUMOR AGENT USING SAME | ZENYAKU KOGYO KABUSHIKIKAISHA (JP) | 2012-03-07 | — | — | EP | disclosed |