Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 8/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | CYP51A1 | Q16850 | 2/20 | 0.45 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GLI1 | P08151 | 1/20 | 0.42 |
| ▸ | GLI2 | P10070 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10339989 | 0.83 | SLC2A1 (0.46) | OPRK1OPRM1OPRD1CYP51A1 | |
| SCHEMBL9813954 | 0.83 | SLC2A1 (0.46) | OPRK1OPRM1OPRD1CYP51A1 | |
| SCHEMBL9813931 | 0.83 | SLC2A1 (0.46) | OPRK1OPRM1OPRD1CYP51A1 | |
| SCHEMBL9813927 | 0.83 | OPRK1 (0.42) | OPRK1OPRM1OPRD1CYP51A1 | |
| Hydrochloric Acid SCHEMBL11479900 | 0.83 | ADRA2A (0.54) | OPRM1KDM4ETAAR1AOC3BCHE | |
| SCHEMBL4479037 | 0.82 | GLI1 (0.50) | OPRK1OPRM1OPRD1KDM4ETAAR1 | |
| SCHEMBL4479042 | 0.82 | GLI1 (0.50) | OPRK1OPRM1OPRD1KDM4ETAAR1 | |
| SCHEMBL10822409 | 0.81 | KDM4E (0.50) | OPRK1OPRM1OPRD1KDM4ETAAR1 | |
| SCHEMBL10822410 | 0.81 | KDM4E (0.50) | OPRK1OPRM1OPRD1KDM4ETAAR1 | |
| SCHEMBL10822407 | 0.81 | KDM4E (0.50) | OPRK1OPRM1OPRD1KDM4ETAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5017619-A | Anitdiabetic | HOFFMANN-LA ROCHE INC. (US) | 1991-05-21 | — | — | US | disclosed |
| EP-0198412-B1 | PHENETHANOL AMINE DERIVATIVES | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1989-03-22 | — | — | EP | disclosed |
| EP-0198412-A1 | Phenethanol amine derivatives | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1986-10-22 | — | — | EP | disclosed |