Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 7/20 | 0.61 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.61 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.54 |
| ▸ | PPARA | Q07869 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ELANE | P08246 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9814061 | 0.98 | ALOX5 (0.59) | ALOX5PTGS2SLC2A1PPARAELANE | |
| SCHEMBL9814049 | 0.98 | ALOX5 (0.59) | ALOX5PTGS2SLC2A1PPARAELANE | |
| SCHEMBL9814043 | 0.98 | ALOX5 (0.59) | ALOX5PTGS2SLC2A1PPARAELANE | |
| SCHEMBL6898660 | 0.94 | ALOX5 (0.53) | ALOX5PTGS2SLC2A1PPARASMN1; SMN2 | |
| Propionaldehyde SCHEMBL27830455 | 0.89 | ALOX5 (0.51) | ALOX5PTGS2SLC2A1PPARAELANE | |
| SCHEMBL27916839 | 0.89 | PTGS2 (0.68) | ALOX5PTGS2SLC2A1PPARAELANE | |
| SCHEMBL7044011 | 0.87 | ALOX5 (0.61) | ALOX5PTGS2SLC2A1PPARAELANE | |
| SCHEMBL23844202 | 0.86 | ALOX5 (0.51) | ALOX5PTGS2SLC2A1PPARASMN1; SMN2 | |
| SCHEMBL27894235 | 0.86 | ALOX5 (0.59) | ALOX5PTGS2SLC2A1PPARAELANE | |
| SCHEMBL8564056 | 0.85 | CA1 (0.48) | ALOX5PTGS2SLC2A1PPARASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3313396-B1 | G PROTEIN-COUPLED RECEPTOR KINASE INHIBITORS AND METHODS FOR USE OF THE SAME | UNIV MICHIGAN REGENTS (US) | 2021-12-15 | — | — | EP | disclosed |
| EP-0295882-B1 | PROCESS FOR INTERMEDIATES TO LEUKOTRIENE ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1991-08-21 | — | — | EP | disclosed |
| EP-0295882-A1 | Process for intermediates to leukotriene antagonists | ELI LILLY AND COMPANY (US) | 1988-12-21 | — | — | EP | disclosed |
| US-4777299-A | Process for leukotriene antagonists | ELI LILLY AND COMPANY (US) | 1988-10-11 | — | — | US | disclosed |