Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Methacrylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methacrylic Acid SCHEMBL2353728 | 0.96 | — | — | |
| Methacrylic Acid SCHEMBL268854 | 0.96 | — | — | |
| Methacrylic Acid SCHEMBL502248 | 0.92 | — | — | |
| Methacrylic Acid SCHEMBL502250 | 0.92 | — | — | |
| Methacrylic Acid SCHEMBL15005463 | 0.92 | TDP1 (0.53) | TDP1FFAR3LCKFYNALDH1A1 | |
| Methacrylic Acid SCHEMBL15043 | 0.92 | TDP1 (0.53) | TDP1FFAR3LCKFYNALDH1A1 | |
| Methacrylic Acid SCHEMBL66252 | 0.92 | TDP1 (0.53) | TDP1FFAR3LCKFYNALDH1A1 | |
| Methacrylic Acid SCHEMBL491341 | 0.92 | TDP1 (0.53) | TDP1FFAR3LCKFYNALDH1A1 | |
| Methacrylic Acid SCHEMBL13234423 | 0.92 | — | — | |
| Methacrylic Acid SCHEMBL11235035 | 0.92 | TDP1 (0.53) | TDP1FFAR3LCKFYNALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5024232-A | Novel radiopaque heavy metal polymer complexes, compositions of matter and articles prepared therefrom | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NY (US) | 1991-06-18 | — | — | US | disclosed |
| US-4882392-A | NONLEACHABLE, TRANSPARENT AND HOMOGENEOUS; ADDITION POLYMERS; MEDICAL DIAGNOSIS, DENTISTRY, GRAFTING AND TEXTILES | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 1989-11-21 | — | — | US | disclosed |