Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 3/20 | 0.44 |
| ▸ | MAOA | P21397 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | KCNN2 | Q9H2S1 | 3/20 | 0.39 |
| ▸ | KCNN3 | Q9UGI6 | 3/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | KCNN1 | Q92952 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11172532 | 0.90 | CA1 (0.47) | CHRNA7MAOATSHRKMT2AMEN1 | |
| SCHEMBL2776134 | 0.89 | HTR2A (0.40) | CHRNA7MAOATSHRABCB1KMT2A | |
| SCHEMBL10763426 | 0.88 | MAOA (0.49) | MAOAALDH1A1 | |
| SCHEMBL13428611 | 0.80 | CYP3A4 (0.43) | MAOATSHRKMT2AMEN1RAD52 | |
| SCHEMBL29693809 | 0.80 | CYP3A4 (0.43) | MAOATSHRKMT2AMEN1RAD52 | |
| SCHEMBL7431595 | 0.80 | CYP3A4 (0.43) | MAOATSHRKMT2AMEN1RAD52 | |
| SCHEMBL333286 | 0.80 | CYP3A4 (0.43) | MAOATSHRKMT2AMEN1RAD52 | |
| SCHEMBL2776426 | 0.79 | NQO2 (0.43) | CHRNA7MAOATSHRKMT2AMEN1 | |
| SCHEMBL8586368 | 0.78 | CHRNA7 (0.47) | CHRNA7MAOAKMT2AMEN1 | |
| SCHEMBL9521714 | 0.78 | CHRNA7 (0.47) | CHRNA7KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0166937-B1 | ADRENERGIC COMPOUNDS | ABBOTT LABORATORIES (US) | 1991-08-28 | — | — | EP | disclosed |
| US-4634705-A | Adrenergic amidines | ABBOTT LABORATORIES (US) | 1987-01-06 | — | — | US | disclosed |
| EP-0166937-A2 | Adrenergic compounds | ABBOTT LABORATORIES (US) | 1986-01-08 | — | — | EP | disclosed |