Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSIP1 | O75475 | 1/20 | 0.38 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 3/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5436496 | 0.83 | APOBEC3A (0.50) | PSIP1APOBEC3AAPOBEC3GTSHRSMN1; SMN2 | |
| Sulfuric Acid SCHEMBL10802033 | 0.82 | PSIP1 (0.39) | PSIP1APOBEC3AAPOBEC3GPTGS2TSHR | |
| Sulfuric Acid SCHEMBL1508282 | 0.82 | PSIP1 (0.39) | PSIP1PTGS2TSHRSMN1; SMN2CES2 | |
| Water SCHEMBL8385260 | 0.81 | APOBEC3A (0.48) | PSIP1APOBEC3AAPOBEC3GTSHRSMN1; SMN2 | |
| Sulfuric Acid SCHEMBL5345728 | 0.79 | APOBEC3A (0.61) | APOBEC3AAPOBEC3GTSHRSMN1; SMN2ACHE | |
| Sulfuric Acid SCHEMBL27613503 | 0.76 | APOBEC3A (0.56) | APOBEC3AAPOBEC3GTSHRSMN1; SMN2ACHE | |
| SCHEMBL5463391 | 0.75 | APEX1 (0.40) | PSIP1APOBEC3AAPOBEC3GKDM4EALDH1A1 | |
| Sulfuric Acid SCHEMBL31286303 | 0.74 | PSIP1 (0.41) | PSIP1APOBEC3AAPOBEC3GACHECES2 | |
| SCHEMBL331964 | 0.74 | PSIP1 (0.41) | PSIP1APOBEC3AAPOBEC3GACHECES2 | |
| SCHEMBL331965 | 0.74 | PSIP1 (0.41) | PSIP1APOBEC3AAPOBEC3GTSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0269884-B1 | CATALYZED ALKYLATION OF HALOPYRIDINATES IN THE ABSENCE OF ADDED ORGANIC SOLVENTS | DOWELANCO (US) | 1991-09-25 | — | — | EP | disclosed |
| EP-0277292-B1 | ORGANIC SOLVENT-FREE PROCESS FOR PREPARING PYRIMIDINYL ORGANOPHOSPHATES | THE DOW CHEMICAL COMPANY (US) | 1991-05-08 | — | — | EP | disclosed |
| EP-0277292-A1 | Organic solvent-free process for preparing pyrimidinyl organophosphates | THE DOW CHEMICAL COMPANY (US) | 1988-08-10 | — | — | EP | disclosed |
| EP-0269884-A1 | Catalyzed alkylation of halopyridinates in the absence of added organic solvents | DOWELANCO (US) | 1988-06-08 | — | — | EP | disclosed |
| US-4701531-A | Catalyzed alkylation of halopyridinates in the absence of added organic solvents | THE DOW CHEMICAL COMPANY (US) | 1987-10-20 | — | — | US | disclosed |
| US-4546189-A | Preparation of cyano(6-(substituted phenoxy)-2-pyridinyl)methyl esters of 3-(2,2-dihaloethenyl)-2,2-dimethylcyclopropane carboxylic acids | THE DOW CHEMICAL COMPANY (US) | 1985-10-08 | — | — | US | disclosed |
| EP-0010891-B1 | HETEROCYCLIC SUBSTITUTED TRIAZOLYL PHOSPHOROUS COMPOUNDS, INSECTICIDAL COMPOSITIONS CONTAINING THEM AND METHOD FOR CONTROLLING INSECTS | THE DOW CHEMICAL COMPANY (US) | 1982-09-01 | — | — | EP | disclosed |
| EP-0050846-A1 | Preparation of cyano (6-(substituted phenoxy)-2-pyridinyl) methyl esters of 3-(2,2-dihaloethenyl)-2,2-dimethyl cyclopropane carboxylic acids | THE DOW CHEMICAL COMPANY (US) | 1982-05-05 | — | — | EP | disclosed |
| US-4224318-A | INSECTICIDES | THE DOW CHEMICAL COMPANY (US) | 1980-09-23 | — | — | US | disclosed |
| US-4223025-A | INSECTICIDES | THE DOW CHEMICAL COMPANY (US) | 1980-09-16 | — | — | US | disclosed |
| EP-0010891-A1 | Heterocyclic substituted triazolyl phosphorous compounds, insecticidal compositions containing them and method for controlling insects | THE DOW CHEMICAL COMPANY (US) | 1980-05-14 | — | — | EP | disclosed |
| US-4147866-A | Process for preparing phosphorothioates and phenylphosphonothioates | THE DOW CHEMICAL COMPANY (US) | 1979-04-03 | — | — | US | disclosed |
| US-4096210-A | REACTING ALKALI METAL PHENATE, PYRIDINATE OR PYRIMIDATE WITH O,O-DIALKYLPHOSPHOROCHLORIDOTHIOATE OR O-ALKYL PHENYLPHOSPHONOCHLORIDOTHIOATE | THE DOW CHEMICAL COMPANY (US) | 1978-06-20 | — | — | US | disclosed |
| US-4007197-A | QUATERNARY AMMONIUM OR PHOSPHONIUM SALT AND TERTIARY AMINE CATALYST | THE DOW CHEMICAL COMPANY (US) | 1977-02-08 | — | — | US | disclosed |