Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | CASR | P41180 | 1/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.46 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.46 |
| ▸ | RAD52 | P43351 | 1/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9815365 | 0.99 | MEN1 (0.55) | MEN1KMT2ACYP2D6GLAMAPT | |
| SCHEMBL11760041 | 0.77 | CYP2D6 (0.68) | MEN1KMT2ACYP2D6GLAMAPT | |
| Hydrochloric Acid SCHEMBL11762436 | 0.75 | CYP2D6 (0.64) | MEN1KMT2ACYP2D6GLAMAPT | |
| SCHEMBL9815375 | 0.72 | CASR (0.51) | MEN1KMT2ACYP2D6CASRADRB2 | |
| Hydrochloric Acid SCHEMBL9815374 | 0.71 | CASR (0.50) | MEN1KMT2ACYP2D6CASRADRB2 | |
| SCHEMBL10769951 | 0.71 | CYP2D6 (0.69) | MEN1KMT2ACYP2D6GLAMAPT | |
| SCHEMBL11236669 | 0.71 | CYP2D6 (0.69) | MEN1KMT2ACYP2D6GLAMAPT | |
| SCHEMBL11576906 | 0.71 | MAPT (0.56) | CYP2D6MAPTHTTCASRADRB2 | |
| SCHEMBL11490643 | 0.70 | GLA (0.57) | MEN1KMT2ACYP2D6GLAMAPT | |
| SCHEMBL1331632 | 0.70 | MEN1 (0.98) | MEN1KMT2ACYP2D6ADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0297435-B1 | AMINOPROPANOL DERIVATIVES OF 3-(3'-HYDROXYPHENYL)-1-PROPANONE, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THESE COMPOUNDS | Helopharm W. Petrik GmbH & Co.KG. (DE) | 1991-10-16 | — | — | EP | claimed |