Proanthocyanidin A2

Proanthocyanidin A2

SCHEMBL981583

Oc1cc(O)c2c(c1)OC1(c3ccc(O)c(O)c3)Oc3cc(O)c4c(c3C2C1O)OC(c1ccc(O)c(O)c1)C(O)C4

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
VEGFA P15692 2/20 1.00
PGF P49763 2/20 1.00
PRKAA2 P54646 1/20 1.00
FLT1 P17948 1/20 0.91
PRKD3 O94806 3/20 0.89
PRKCG P05129 3/20 0.89
PRKCB P05771 3/20 0.89
PRKCA P17252 3/20 0.89
PRKCH P24723 3/20 0.89
PRKCI P41743 3/20 0.89
PRKCE Q02156 3/20 0.89
PRKCQ Q04759 3/20 0.89
PRKCZ Q05513 3/20 0.89
PRKCD Q05655 3/20 0.89
PRKD1 Q15139 3/20 0.89
PDE4D Q08499 1/20 0.79
SNCA P37840 3/20 0.65
HSD17B10 Q99714 3/20 0.65
ALOX15 P16050 2/20 0.65
CYP1A2 P05177 1/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Proanthocyanidin A2 SCHEMBL14273881 1.00 VEGFA (1.00) VEGFAPGFPRKAA2FLT1PRKD3
Proanthocyanidin A2 SCHEMBL13285132 1.00 VEGFA (1.00) VEGFAPGFPRKAA2FLT1PRKD3
Proanthocyanidin A2 SCHEMBL18350173 1.00 VEGFA (1.00) VEGFAPGFPRKAA2FLT1PRKD3
Proanthocyanidin A1 SCHEMBL1689429 1.00 VEGFA (1.00) VEGFAPGFPRKAA2FLT1PRKD3
Proanthocyanidin A2 SCHEMBL15398842 1.00 VEGFA (1.00) VEGFAPGFPRKAA2FLT1PRKD3
Proanthocyanidin A2 SCHEMBL981582 1.00 VEGFA (1.00) VEGFAPGFPRKAA2FLT1PRKD3
Proanthocyanidin A2 SCHEMBL15394643 1.00 VEGFA (1.00) VEGFAPGFPRKAA2FLT1PRKD3
Proanthocyanidin A2 SCHEMBL18214185 1.00 VEGFA (1.00) VEGFAPGFPRKAA2FLT1PRKD3
Proanthocyanidin A2 SCHEMBL15399757 1.00 VEGFA (1.00) VEGFAPGFPRKAA2FLT1PRKD3
Proanthocyanidin A2 SCHEMBL29551197 1.00 VEGFA (1.00) VEGFAPGFPRKAA2FLT1PRKD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 381 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025064839-A1 COMPOSITIONS AND METHODS RELATED TO THE SIMULTANEOUS MANUFACTURE AND PURIFICATION OF FLAVOR AND FRAGRANCE MOLECULES Natural Extraction Systems, LLC (US) 2025-03-27 WO claimed
EP-4493552-A2 COMPOSITIONS AND METHODS RELATED TO THE SIMULTANEOUS MANUFACTURE AND PURIFICATION OF FLAVOR AND FRAGRANCE MOLECULES Natural Extraction Systems, LLC (US) 2025-01-22 EP claimed
CN-118576788-B Super-hydrophilic coating with anticoagulation and anti-inflammatory functions, preparation method and application 四川大学 2024-12-20 CN claimed
CN-118576788-A Super-hydrophilic coating with anticoagulation and anti-inflammatory functions, preparation method and application 四川大学 2024-09-03 CN claimed
CN-117860664-A Procyanidine injectable hydrogel and preparation method and application thereof 安徽中医药大学 2024-04-12 CN claimed
WO-2023219526-A1 MULTITARGET ANTIVIRAL DIETARY SUPPLEMENT PROKIN MILAN (RS) 2023-11-16 WO claimed
CN-117018303-A Surface hydrophilic coating of medical material and preparation method thereof 江门市泰乐医疗科技有限公司 2023-11-10 CN claimed
WO-2023178172-A2 COMPOSITIONS AND METHODS RELATED TO THE SIMULTANEOUS MANUFACTURE AND PURIFICATION OF FLAVOR AND FRAGRANCE MOLECULES Natural Extraction Systems, LLC (US) 2023-09-21 WO claimed
WO-2022023960-A1 METHODS OF TREATING AND PREVENTING CORONAVIRUS INFECTION AND DISRUPTING CORONAVIRUS REPLICATION FUNDACIÓN UNIVERSITARIA SAN ANTONIO (UCAM) (ES) 2022-02-03 WO claimed
US-20210146006-A1 COMPOSITE CONTAINING COLLAGEN AND ELASTIN AS A DERMAL EXPANDER AND TISSUE FILLER TRUELASTIN LABORATORIES, INC. 2021-05-20 US claimed
US-6429202-B1 ADMINISTERING COMPLEX WITH PHOSPHOLIPIDS TO PREVENT ATHEROSCLEROSIS AND MYOCARDIAL OR CEREBRAL INFARCTIONS; REDUCES FORMATION OF ARTERIAL PLAQUES INDENA S.P.A. (IT) 2002-08-06 US claimed
EP-0659402-B1 Formulations containing carotenoids and procarotenoids combined with polyphenols in the prevention of the damages due to an abnormal production of free radicals INDENA SPA (IT) 2002-03-13 EP claimed
CN-1330548-A Phospholipid complexes of proanthocyanidin A2 for use as anti-atherosclerotic agents INDANE S P A (IT) 2002-01-09 CN claimed
EP-1140115-A2 PHOSPHOLIPID COMPLEXES OF PROANTHOCYANIDIN A2 AS ANTIATHEROSCLEROTIC AGENTS INDENA S.p.A. (IT) 2001-10-10 EP claimed
EP-0694305-B1 Pharmaceutical or cosmetic formulations containing coumarins and proanthocyanidins INDENA SPA (IT) 2001-02-28 EP claimed
WO-2000037062-A2 PHOSPHOLIPID COMPLEXES OF PROANTHOCYANIDIN A2 AS ANTIATHEROSCLEROTIC AGENTS INDENA S.P.A. (IT) 2000-06-29 WO claimed
US-5665365-A Formulations containing coumarins and the use thereof in the pharmaceutical and cosmetic fields INDENA S.P.A. (IT) 1997-09-09 US claimed
EP-0694305-A1 Pharmaceutical or cosmetic formulations containing coumarins and proanthocyanidinis INDENA S.p.A. (IT) 1996-01-31 EP claimed
EP-0659402-A2 Formulations containing carotenoids and procarotenoids combined with polyphenols in the prevention of the damages due to an abnormal production of free radicals INDENA S.p.A. (IT) 1995-06-28 EP claimed
EP-0210785-B1 PROCESS FOR OBTAINING PROANTHOCYANIDINE A2, PHARMACEUTICAL COMPOSITIONS AND THEIR THERAPEUTIC USE IDB HOLDING S.p.A. (IT) 1990-09-26 EP claimed