Proanthocyanidin A2

Proanthocyanidin A2

SCHEMBL15399757

Oc1cc(O)c2c(c1)O[C@]1(c3ccc(O)c(O)c3)Oc3cc(O)c4c(c3[C@H]2[C@@H]1O)O[C@H](c1ccc(O)c(O)c1)[C@H](O)C4

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
VEGFA P15692 2/20 1.00
PGF P49763 2/20 1.00
PRKAA2 P54646 1/20 1.00
FLT1 P17948 1/20 0.91
PRKD3 O94806 3/20 0.89
PRKCG P05129 3/20 0.89
PRKCB P05771 3/20 0.89
PRKCA P17252 3/20 0.89
PRKCH P24723 3/20 0.89
PRKCI P41743 3/20 0.89
PRKCE Q02156 3/20 0.89
PRKCQ Q04759 3/20 0.89
PRKCZ Q05513 3/20 0.89
PRKCD Q05655 3/20 0.89
PRKD1 Q15139 3/20 0.89
PDE4D Q08499 1/20 0.79
SNCA P37840 3/20 0.65
HSD17B10 Q99714 3/20 0.65
ALOX15 P16050 2/20 0.65
CYP1A2 P05177 1/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Proanthocyanidin A2 SCHEMBL981583 1.00 VEGFA (1.00) VEGFAPGFPRKAA2FLT1PRKD3
Proanthocyanidin A2 SCHEMBL14273881 1.00 VEGFA (1.00) VEGFAPGFPRKAA2FLT1PRKD3
Proanthocyanidin A2 SCHEMBL13285132 1.00 VEGFA (1.00) VEGFAPGFPRKAA2FLT1PRKD3
Proanthocyanidin A2 SCHEMBL18350173 1.00 VEGFA (1.00) VEGFAPGFPRKAA2FLT1PRKD3
Proanthocyanidin A1 SCHEMBL1689429 1.00 VEGFA (1.00) VEGFAPGFPRKAA2FLT1PRKD3
Proanthocyanidin A2 SCHEMBL15398842 1.00 VEGFA (1.00) VEGFAPGFPRKAA2FLT1PRKD3
Proanthocyanidin A2 SCHEMBL981582 1.00 VEGFA (1.00) VEGFAPGFPRKAA2FLT1PRKD3
Proanthocyanidin A2 SCHEMBL15394643 1.00 VEGFA (1.00) VEGFAPGFPRKAA2FLT1PRKD3
Proanthocyanidin A2 SCHEMBL18214185 1.00 VEGFA (1.00) VEGFAPGFPRKAA2FLT1PRKD3
Proanthocyanidin A2 SCHEMBL29551197 1.00 VEGFA (1.00) VEGFAPGFPRKAA2FLT1PRKD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11357811-B2 Methods to isolate anti-microbials from fruit or seed extracts WISYS TECHNOLOGY FOUNDATION, INC. (US) 2022-06-14 US disclosed
US-20160324912-A1 METHODS TO ISOLATE ANTI-MICROBIALS FROM FRUIT OR SEED EXTRACTS WISYS TECHNOLOGY FOUNDATION, INC. 2016-11-10 US disclosed
US-20140004214-A1 METHODS TO ISOLATE ANTI-MICROBIALS FROM FRUIT OR SEED EXTRACTS WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2014-01-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160324912-A1 METHODS TO ISOLATE ANTI-MICROBIALS FROM FRUIT OR SEED EXTRACTS MGAM, PRUNE1, GANC VEGFA 4460/4885PGF 2153/4885PRKAA2 3041/4885
US-11357811-B2 Methods to isolate anti-microbials from fruit or seed extracts MGAM, PRUNE1, GANC VEGFA 4460/4885PGF 2153/4885PRKAA2 3041/4885
US-20140004214-A1 METHODS TO ISOLATE ANTI-MICROBIALS FROM FRUIT OR SEED EXTRACTS MGAM, PRUNE1, GANC VEGFA 4460/4885PGF 2153/4885PRKAA2 3041/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.