Proanthocyanidin A1

Proanthocyanidin A1

SCHEMBL1689429

Oc1cc(O)c2c(c1)O[C@@]1(c3ccc(O)c(O)c3)Oc3cc(O)c4c(c3[C@@H]2[C@H]1O)O[C@H](c1ccc(O)c(O)c1)[C@@H](O)C4

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
VEGFA P15692 2/20 1.00
PGF P49763 2/20 1.00
PRKAA2 P54646 1/20 1.00
FLT1 P17948 1/20 0.91
PRKD3 O94806 3/20 0.89
PRKCG P05129 3/20 0.89
PRKCB P05771 3/20 0.89
PRKCA P17252 3/20 0.89
PRKCH P24723 3/20 0.89
PRKCI P41743 3/20 0.89
PRKCE Q02156 3/20 0.89
PRKCQ Q04759 3/20 0.89
PRKCZ Q05513 3/20 0.89
PRKCD Q05655 3/20 0.89
PRKD1 Q15139 3/20 0.89
PDE4D Q08499 1/20 0.79
SNCA P37840 3/20 0.65
HSD17B10 Q99714 3/20 0.65
ALOX15 P16050 2/20 0.65
CYP1A2 P05177 1/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Proanthocyanidin A2 SCHEMBL981583 1.00 VEGFA (1.00) VEGFAPGFPRKAA2FLT1PRKD3
Proanthocyanidin A2 SCHEMBL14273881 1.00 VEGFA (1.00) VEGFAPGFPRKAA2FLT1PRKD3
Proanthocyanidin A2 SCHEMBL13285132 1.00 VEGFA (1.00) VEGFAPGFPRKAA2FLT1PRKD3
Proanthocyanidin A2 SCHEMBL18350173 1.00 VEGFA (1.00) VEGFAPGFPRKAA2FLT1PRKD3
Proanthocyanidin A2 SCHEMBL15398842 1.00 VEGFA (1.00) VEGFAPGFPRKAA2FLT1PRKD3
Proanthocyanidin A2 SCHEMBL981582 1.00 VEGFA (1.00) VEGFAPGFPRKAA2FLT1PRKD3
Proanthocyanidin A2 SCHEMBL15394643 1.00 VEGFA (1.00) VEGFAPGFPRKAA2FLT1PRKD3
Proanthocyanidin A2 SCHEMBL18214185 1.00 VEGFA (1.00) VEGFAPGFPRKAA2FLT1PRKD3
Proanthocyanidin A2 SCHEMBL15399757 1.00 VEGFA (1.00) VEGFAPGFPRKAA2FLT1PRKD3
Proanthocyanidin A2 SCHEMBL29551197 1.00 VEGFA (1.00) VEGFAPGFPRKAA2FLT1PRKD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 79 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022023960-A1 METHODS OF TREATING AND PREVENTING CORONAVIRUS INFECTION AND DISRUPTING CORONAVIRUS REPLICATION FUNDACIÓN UNIVERSITARIA SAN ANTONIO (UCAM) (ES) 2022-02-03 WO claimed
US-20210146006-A1 COMPOSITE CONTAINING COLLAGEN AND ELASTIN AS A DERMAL EXPANDER AND TISSUE FILLER TRUELASTIN LABORATORIES, INC. 2021-05-20 US claimed
US-10583218-B2 Composite containing collagen and elastin as a dermal expander and tissue filler HANCOCK JAFFE LABORATORIES AESTHETICS, INC. (US) 2020-03-10 US claimed
CN-106265627-A Method for treating inflammatory diseases and application of proanthocyanidin compound as medicine for treating inflammatory diseases 香港浸会大学 2017-01-04 CN claimed
US-20160374985-A1 Bioactivity proanthocyanidin compound isolated from Lasia spinosa (L.) Thwait UNIV HONG KONG BAPTIST UNIV (HK) 2016-12-29 US claimed
CN-103619414-A Hair dyeing process employing at least one dihydroxyflavanol, a manganese or zinc salt, hydrogen peroxide, (bi)carbonate, an alkaline agent and a magnesium, molybdenum or calcium salt OREAL 2014-03-05 CN claimed
US-20120010146-A1 COMPOSITE CONTAINING COLLAGEN AND ELASTIN AS A DERMAL EXPANDER AND TISSUE FILLER HANCOCK JAFFE LABORATORIES, INC. (US) 2012-01-12 US claimed
WO-2010053918-A1 COMPOSITE CONTAINING COLLAGEN AND ELASTIN AS A DERMAL EXPANDER AND TISSUE FILLER HANCOCK JAFFE LABORATORIES, INC. (US) 2010-05-14 WO claimed
EP-4079737-B1 SYSTEM AND METHOD FOR SOLUTION PHASE GAP PEPTIDE SYNTHESIS UNIV TEXAS TECH SYSTEM (US) 2026-02-11 EP disclosed
US-12344632-B2 System and method for solution phase gap peptide synthesis TEXAS TECH UNIVERSITY SYSTEM (US) 2025-07-01 US disclosed
US-20250206710-A1 COMPOSITIONS AND METHODS RELATED TO THE SIMULTANEOUS MANUFACTURE AND PURIFICATION OF FLAVOR AND FRAGRANCE MOLECULES NATURAL EXTRACTION SYS LLC (US) 2025-06-26 US disclosed
US-20250154118-A1 Compositions and Methods Related to the Simultaneous Manufacture and Purification of Flavor and Fragrance Molecules NATURAL EXTRACTION SYS LLC (US) 2025-05-15 US disclosed
EP-3891204-B1 POLYCARBOXYLIC ACID COMPOUNDS FOR THE TREATMENT OF FIBROUS AMINO ACID BASED SUBSTRATES, ESPECIALLY HAIR MOMENTIVE PERFORMANCE MAT INC (US) 2025-04-09 EP disclosed
CN-113164357-B Use of polycarboxylic acid compounds for treating fibrous substrates based on amino acids, in particular hair 迈图高新材料公司 2024-12-10 CN disclosed
CN-101862270-A Composition comprising ortho-diphenol, metal salt, hydrogen peroxide, (bi)carbonate OREAL 2010-10-20 CN disclosed
CN-101791269-A Use contains the colouring method of the compositions of at least a neighbour-Benzodiazepines, a kind of slaine, hydrogen peroxide and carbonate or bicarbonate OREAL 2010-08-04 CN disclosed
CN-101785746-A Use the colouring method that comprises wiping, drying or non-rinse step of neighbour-Benzodiazepines OREAL 2010-07-28 CN disclosed
WO-2010053918-A1 COMPOSITE CONTAINING COLLAGEN AND ELASTIN AS A DERMAL EXPANDER AND TISSUE FILLER HANCOCK JAFFE LABORATORIES, INC. (US) 2010-05-14 WO disclosed
US-20080090898-A1 Boosting immunity MARS, INCORPORATED (US) 2008-04-17 US disclosed
US-20070004652-A1 Treatment of occlusive thrombosis MARS, INCORPORATED (US) 2007-01-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12344632-B2 System and method for solution phase gap peptide synthesis SBDS, NGLY1, GAP43 VEGFA 1986/4885PGF 2658/4885PRKAA2 3346/4885
US-20160374985-A1 Bioactivity proanthocyanidin compound isolated from Lasia spinosa (L.) Thwait MPO, MMP10, SERPINB1 VEGFA 714/4885PGF 1385/4885PRKAA2 2353/4885
US-20080090898-A1 Boosting immunity TLR7, TLR1, MYD88 VEGFA 2121/4885PGF 907/4885PRKAA2 2755/4885
US-20070004652-A1 Treatment of occlusive thrombosis PROC, F2, SERPINC1 VEGFA 75/4885PGF 171/4885PRKAA2 4487/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.