Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.61 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.61 |
| ▸ | ABCB1 | P08183 | 7/20 | 0.58 |
| ▸ | HTR7 | P34969 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 5/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.55 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.55 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 1/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.55 |
| ▸ | DRD2 | P14416 | 1/20 | 0.55 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.55 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9815989 | 0.91 | ABCB1 (0.60) | KCNH2CACNA1GABCB1MAPTALDH1A1 | |
| SCHEMBL9815959 | 0.89 | ABCB1 (0.74) | ABCB1HTR7 | |
| SCHEMBL10839674 | 0.86 | HTR7 (0.73) | ABCB1HTR7MAPTALDH1A1LMNA | |
| SCHEMBL10837921 | 0.84 | CACNA1G (0.65) | KCNH2CACNA1GABCB1HTR7MAPT | |
| SCHEMBL9815996 | 0.83 | ABCB1 (0.61) | ABCB1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL11491672 | 0.81 | CACNA1G (0.60) | KCNH2CACNA1GABCB1MAPTALDH1A1 | |
| SCHEMBL30383961 | 0.81 | KCNH2 (0.61) | KCNH2CACNA1GABCB1HTR7MAPT | |
| SCHEMBL3440691 | 0.81 | KCNH2 (0.61) | KCNH2CACNA1GABCB1HTR7MAPT | |
| SCHEMBL3440692 | 0.81 | KCNH2 (0.61) | KCNH2CACNA1GABCB1HTR7MAPT | |
| SCHEMBL17313697 | 0.81 | KCNH2 (0.78) | KCNH2CACNA1GABCB1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0167121-B1 | SUBSTITUTED PHENYLPIPERAZINYL PROPANOLS, PROCESS FOR THEIR PREPARATION, THEIR USE, AND COMPOSITIONS CONTAINING THESE COMPOUNDS | Beiersdorf Aktiengesellschaft (DE) | 1991-10-23 | — | — | EP | disclosed |
| US-4631281-A | ANTICOAGULANTS, ASTHMA, HYPOTENSIVE AGENTS, BRONCHOPILATORS, INOTROPIC AGENTS | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1986-12-23 | — | — | US | disclosed |
| EP-0167121-A2 | Substituted phenylpiperazinyl propanols, process for their preparation, their use, and compositions containing these compounds | Beiersdorf Aktiengesellschaft (DE) | 1986-01-08 | — | — | EP | disclosed |