Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 3/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.48 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | SCN1A | P35498 | 1/20 | 0.41 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.41 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.39 |
| ▸ | HTR3B | O95264 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12806774 | 0.89 | CHRM2 (0.47) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL12806749 | 0.86 | CHRM3 (0.48) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL8013935 | 0.84 | CYP2B6 (0.52) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL597167 | 0.84 | CYP2B6 (0.52) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL18284710 | 0.83 | ADRB1 (0.45) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL7547849 | 0.83 | CYP2B6 (0.55) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Hydrochloric Acid SCHEMBL8017738 | 0.83 | CYP2B6 (0.50) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL1208824 | 0.82 | CHRM2 (0.47) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL4541997 | 0.80 | KCNA5 (0.48) | OPRD1KMT2ALMNAMEN1KCNA5 | |
| SCHEMBL8818968 | 0.79 | CHRM2 (0.43) | CHRM2CHRM4CHRM5CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101512336-A | Stimulation of pancreatic beta cell proliferation | UNIV ROCKEFELLER (US) | 2009-08-19 | — | — | CN | claimed |
| EP-0167121-B1 | SUBSTITUTED PHENYLPIPERAZINYL PROPANOLS, PROCESS FOR THEIR PREPARATION, THEIR USE, AND COMPOSITIONS CONTAINING THESE COMPOUNDS | Beiersdorf Aktiengesellschaft (DE) | 1991-10-23 | — | — | EP | claimed |
| US-4631281-A | ANTICOAGULANTS, ASTHMA, HYPOTENSIVE AGENTS, BRONCHOPILATORS, INOTROPIC AGENTS | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1986-12-23 | — | — | US | claimed |
| EP-0167121-A2 | Substituted phenylpiperazinyl propanols, process for their preparation, their use, and compositions containing these compounds | Beiersdorf Aktiengesellschaft (DE) | 1986-01-08 | — | — | EP | claimed |
| CN-101512336-A | Stimulation of pancreatic beta cell proliferation | UNIV ROCKEFELLER (US) | 2009-08-19 | — | — | CN | disclosed |
| EP-0167121-B1 | SUBSTITUTED PHENYLPIPERAZINYL PROPANOLS, PROCESS FOR THEIR PREPARATION, THEIR USE, AND COMPOSITIONS CONTAINING THESE COMPOUNDS | Beiersdorf Aktiengesellschaft (DE) | 1991-10-23 | — | — | EP | disclosed |
| EP-0167121-B1 | SUBSTITUTED PHENYLPIPERAZINYL PROPANOLS, PROCESS FOR THEIR PREPARATION, THEIR USE, AND COMPOSITIONS CONTAINING THESE COMPOUNDS | Beiersdorf Aktiengesellschaft (DE) | 1991-10-23 | — | — | EP | disclosed |
| US-4994459-A | Aryloxypropane substituted piperazine derivatives with antiarrhythmic and antifibrillatory activity | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-02-19 | — | — | US | disclosed |
| US-4631281-A | ANTICOAGULANTS, ASTHMA, HYPOTENSIVE AGENTS, BRONCHOPILATORS, INOTROPIC AGENTS | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1986-12-23 | — | — | US | disclosed |
| US-4631281-A | ANTICOAGULANTS, ASTHMA, HYPOTENSIVE AGENTS, BRONCHOPILATORS, INOTROPIC AGENTS | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1986-12-23 | — | — | US | disclosed |
| US-4631281-A | ANTICOAGULANTS, ASTHMA, HYPOTENSIVE AGENTS, BRONCHOPILATORS, INOTROPIC AGENTS | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1986-12-23 | — | — | US | disclosed |
| EP-0167121-A2 | Substituted phenylpiperazinyl propanols, process for their preparation, their use, and compositions containing these compounds | Beiersdorf Aktiengesellschaft (DE) | 1986-01-08 | — | — | EP | disclosed |
| EP-0034276-B1 | PHENYLPIPERAZINE DERIVATIVES OF 1,3,4-OXADIAZOLYL PHENOLS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BASF Aktiengesellschaft (DE) | 1983-11-09 | — | — | EP | disclosed |
| US-4353904-A | TREATMENT OF HYPERTONIA | BASF AKTIENGESELLSCHAFT (DE) | 1982-10-12 | — | — | US | disclosed |
| US-4353904-A | TREATMENT OF HYPERTONIA | BASF AKTIENGESELLSCHAFT (DE) | 1982-10-12 | — | — | US | disclosed |
| EP-0056866-A2 | Phenylpiperazine derivatives of heterylphenols and hetarylanilines, their preparation and their pharmaceutical compositions | BASF Aktiengesellschaft (DE) | 1982-08-04 | — | — | EP | disclosed |
| EP-0056486-A2 | Phenylpiperazinyl-propanoles of hetarylphenols, their preparation and their pharmaceutical compositions | BASF Aktiengesellschaft (DE) | 1982-07-28 | — | — | EP | disclosed |
| EP-0056486-A2 | Phenylpiperazinyl-propanoles of hetarylphenols, their preparation and their pharmaceutical compositions | BASF Aktiengesellschaft (DE) | 1982-07-28 | — | — | EP | disclosed |
| EP-0056486-A2 | Phenylpiperazinyl-propanoles of hetarylphenols, their preparation and their pharmaceutical compositions | BASF Aktiengesellschaft (DE) | 1982-07-28 | — | — | EP | disclosed |
| EP-0034276-A2 | Phenylpiperazine derivatives of 1,3,4-oxadiazolyl phenols, their preparation and pharmaceutical compositions containing them | BASF Aktiengesellschaft (DE) | 1981-08-26 | — | — | EP | disclosed |