Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.37 |
| ▸ | NPC1 | O15118 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 5/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1805432 | 0.82 | PTPN1 (0.44) | RAB9ANPC1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL3066466 | 0.82 | ALDH1A1 (0.42) | RAB9ANPC1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL2373540 | 0.80 | SMN1; SMN2 (0.49) | RAB9ANPC1HPGDSMN1; SMN2MAPT | |
| SCHEMBL18819583 | 0.80 | SMN1; SMN2 (0.40) | RAB9ANPC1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL9593485 | 0.77 | RAB9A (0.57) | RAB9ANPC1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL5243287 | 0.76 | MRGPRX4 (0.51) | RAB9ANPC1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL3066648 | 0.76 | ALDH1A1 (0.60) | RAB9ANPC1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL10925695 | 0.74 | GSK3B (0.43) | RAB9ANPC1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL892010 | 0.73 | CYP1A2 (0.46) | RAB9ANPC1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL10925057 | 0.73 | ALDH1A1 (0.57) | RAB9ANPC1ALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5059614-A | NOVEL ISOXAZOLE AND ISOXAZOLINE COMPOUNDS WITH ANTICONVULSANT ACTIVITY PROCESS FOR THEIR PREPARATION AND THERAPEUTIC COMPOSITION CONTAINING THEM | NOVAPHARME (FR) | 1991-10-22 | — | — | US | disclosed |
| EP-0123418-B1 | 4-HYDROXY-N-(5((SUBSTITUTED HETERO) METHYL)-3-ISOXAZOLYL-2H-1,2-BENZOTHIAZINE-3-CARBOXAMIDE,1,1-DIOXIDE AND 4-HYDROXY-2-ALKYL-N-(5-((SUBSTITUTED HETERO) METHYL)-3-ISOXAZOLYL)2H-1,2-BENZOTHIAZINE-3-CARBOXAMIDE,1,1-DIOXIDE | WARNER-LAMBERT COMPANY (US) | 1988-01-20 | — | — | EP | disclosed |
| US-4581458-A | 5-substituted-3-aminoisoxazole compounds | WARNER-LAMBERT COMPANY (US) | 1986-04-08 | — | — | US | disclosed |
| US-4489077-A | 3-Isoxa-zolyl-2H-1,2-benzothiazine-3-carboxamide, 1,1-dioxides | WARNER-LAMBERT COMPANY (US) | 1984-12-18 | — | — | US | disclosed |
| EP-0123418-A1 | 4-Hydroxy-N-(5((substituted hetero) methyl)-3-isoxazolyl-2H-1,2-benzothiazine-3-carboxamide,1,1-dioxide and 4-hydroxy-2-alkyl-N-(5-((substituted hetero) methyl)-3-isoxazolyl)2H-1,2-benzothiazine-3-carboxamide,1,1-dioxide | WARNER-LAMBERT COMPANY (US) | 1984-10-31 | — | — | EP | disclosed |