Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | CDC25A | P30304 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30345054 | 0.85 | ALDH1A1 (0.46) | ALDH1A1KDM4EHPGDNPSR1EGFR | |
| SCHEMBL24664741 | 0.81 | ALDH1A1 (0.65) | ALDH1A1KDM4EHPGDNPSR1EGFR | |
| SCHEMBL8727194 | 0.79 | CDC25A (0.63) | ALDH1A1KDM4EHPGDNPSR1EGFR | |
| SCHEMBL8488571 | 0.78 | ALDH1A1 (0.53) | ALDH1A1KDM4EHPGDNPSR1EGFR | |
| SCHEMBL7383673 | 0.78 | CDC25A (0.48) | ALDH1A1KDM4EHPGDNPSR1EGFR | |
| SCHEMBL27369982 | 0.77 | ALDH1A1 (0.47) | ALDH1A1KDM4EHPGDNPSR1EGFR | |
| SCHEMBL24665805 | 0.77 | ALDH1A1 (0.47) | ALDH1A1KDM4EHPGDNPSR1EGFR | |
| SCHEMBL16822181 | 0.77 | ALDH1A1 (0.47) | ALDH1A1KDM4EHPGDNPSR1EGFR | |
| Hydrochloric Acid SCHEMBL16822115 | 0.75 | MEN1 (0.47) | ALDH1A1KDM4EHPGDNPSR1EGFR | |
| SCHEMBL17974970 | 0.74 | MEN1 (0.49) | ALDH1A1KDM4EHPGDEGFRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0126635-B1 | NOVEL OXINDOLE DERIVATIVE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-12-18 | — | — | EP | disclosed |
| US-4694017-A | 2-amido 3(oxindol-3-yl)propionic acids having antiulcer activity | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1987-09-15 | — | — | US | disclosed |
| EP-0126635-A2 | Novel oxindole derivative | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-11-28 | — | — | EP | disclosed |