Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 4/20 | 0.45 |
| ▸ | MMP1 | P03956 | 2/20 | 0.43 |
| ▸ | FCER2 | P06734 | 3/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | ERAP2 | Q6P179 | 4/20 | 0.40 |
| ▸ | LNPEP | Q9UIQ6 | 4/20 | 0.40 |
| ▸ | ERAP1 | Q9NZ08 | 3/20 | 0.40 |
| ▸ | GNPAT | O15228 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11765581 | 0.87 | REN (0.54) | RENMMP1FCER2CTSLPTPN1 | |
| SCHEMBL11759100 | 0.87 | REN (0.54) | RENMMP1FCER2CTSLPTPN1 | |
| Hydrochloric Acid SCHEMBL11764160 | 0.86 | REN (0.53) | RENMMP1FCER2CTSLPTPN1 | |
| SCHEMBL7271435 | 0.85 | CTSL (0.50) | RENMMP1FCER2CTSLPTPN1 | |
| SCHEMBL9551311 | 0.84 | REN (0.64) | RENCTSLACE | |
| SCHEMBL10605598 | 0.84 | PTPN1 (0.52) | RENMMP1FCER2CTSLPTPN1 | |
| SCHEMBL9417261 | 0.84 | REN (0.48) | RENMMP1FCER2CTSLPTPN1 | |
| SCHEMBL9417336 | 0.83 | REN (0.48) | RENMMP1FCER2CTSLPTPN1 | |
| SCHEMBL7277904 | 0.82 | FCER2 (0.45) | RENMMP1FCER2CTSLPTPN1 | |
| SCHEMBL9472410 | 0.82 | REN (0.47) | RENMMP1FCER2CTSLPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5032577-A | Hypotensive | ABBOTT LABORATORIES (US) | 1991-07-16 | — | — | US | disclosed |
| EP-0295294-A4 | PEPTIDYLAMINODIOLS. | ABBOTT LAB (US) | 1990-04-10 | — | — | EP | disclosed |
| EP-0295294-A1 | PEPTIDYLAMINODIOLS | ABBOTT LABORATORIES (US) | 1988-12-21 | — | — | EP | disclosed |
| WO-1988005050-A1 | PEPTIDYLAMINODIOLS | ABBOTT LABORATORIES (US) | 1988-07-14 | — | — | WO | disclosed |