Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 5/20 | 0.74 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9818913 | 0.85 | AKR1B1 (1.00) | AKR1B1KMT2A | |
| SCHEMBL9819088 | 0.83 | AKR1B1 (0.72) | AKR1B1MAPTKDM4EALDH1A1GAA | |
| SCHEMBL10487778 | 0.81 | AKR1B1 (0.75) | AKR1B1 | |
| SCHEMBL9818775 | 0.78 | AKR1B1 (0.71) | AKR1B1KDM4EALDH1A1GAAHPGD | |
| SCHEMBL21750776 | 0.73 | AKR1B1 (0.62) | AKR1B1MAPTALDH1A1KMT2ARAB9A | |
| SCHEMBL9818883 | 0.72 | AKR1B1 (0.72) | AKR1B1MAPTKDM4EALDH1A1GAA | |
| SCHEMBL27313536 | 0.72 | SMN1; SMN2 (0.44) | AKR1B1MAPTKDM4EALDH1A1GAA | |
| SCHEMBL11105548 | 0.71 | MAPT (0.43) | AKR1B1MAPTGLO1KDM4EALDH1A1 | |
| SCHEMBL11108081 | 0.71 | MAPT (0.43) | AKR1B1MAPTGLO1KDM4EALDH1A1 | |
| SCHEMBL27780980 | 0.70 | ALDH1A1 (0.47) | AKR1B1MAPTGLO1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0230379-B1 | CHROMAN- AND THIOCHROMAN-4-ACETIC ACIDS USEFUL IN THE TREATMENT OF DIABETIC COMPLICATIONS | PFIZER INC. (US) | 1991-04-03 | — | — | EP | disclosed |
| US-4853410-A | Hydroxyacetic acid derivatives for the treatment of diabetic complications | PFIZER INC. (US) | 1989-08-01 | — | — | US | disclosed |
| WO-1987004344-A1 | HYDROXYACETIC ACID DERIVATIVES FOR THE TREATMENT OF DIABETIC COMPLICATIONS | PFIZER INC. (US) | 1987-07-30 | — | — | WO | disclosed |
| EP-0230379-A2 | Chroman- and thiochroman-4-acetic acids useful in the treatment of diabetic complications | PFIZER INC. (US) | 1987-07-29 | — | — | EP | disclosed |