Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | PPARG | P37231 | 6/20 | 0.50 |
| ▸ | PPARA | Q07869 | 6/20 | 0.50 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10487454 | 0.88 | RAB9A (0.51) | RAB9AMAPTPPARGPPARACA1 | |
| SCHEMBL11946585 | 0.81 | CA1 (0.53) | RAB9AMAPTCA1CA2NPC1 | |
| SCHEMBL9818882 | 0.81 | PPARG (0.60) | RAB9AMAPTPPARGPPARA | |
| SCHEMBL8326403 | 0.80 | MAPT (0.51) | RAB9AMAPTCA1CA2NPC1 | |
| SCHEMBL7323557 | 0.79 | SMN1; SMN2 (0.57) | RAB9AMAPTPPARGPPARACA1 | |
| SCHEMBL7324691 | 0.77 | NR4A1 (0.57) | PPARGPPARAKMT2A | |
| SCHEMBL3984258 | 0.77 | MAPT (0.55) | RAB9AMAPTCA1CA2NPC1 | |
| SCHEMBL3979307 | 0.76 | NR1H2 (0.52) | RAB9AMAPTPPARGPPARANPC1 | |
| SCHEMBL3979305 | 0.76 | NR1H2 (0.52) | RAB9AMAPTPPARGPPARANPC1 | |
| SCHEMBL9818873 | 0.76 | PPARG (0.46) | PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0230379-B1 | CHROMAN- AND THIOCHROMAN-4-ACETIC ACIDS USEFUL IN THE TREATMENT OF DIABETIC COMPLICATIONS | PFIZER INC. (US) | 1991-04-03 | — | — | EP | disclosed |
| US-4853410-A | Hydroxyacetic acid derivatives for the treatment of diabetic complications | PFIZER INC. (US) | 1989-08-01 | — | — | US | disclosed |
| WO-1987004344-A1 | HYDROXYACETIC ACID DERIVATIVES FOR THE TREATMENT OF DIABETIC COMPLICATIONS | PFIZER INC. (US) | 1987-07-30 | — | — | WO | disclosed |
| EP-0230379-A2 | Chroman- and thiochroman-4-acetic acids useful in the treatment of diabetic complications | PFIZER INC. (US) | 1987-07-29 | — | — | EP | disclosed |