Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | FADS1 | O60427 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL633344 | 0.89 | HTT (0.54) | LMNAHTTMEN1KMT2AMAPT | |
| SCHEMBL5583614 | 0.83 | ALOX15 (0.60) | LMNAHTTMEN1KMT2AMAPT | |
| SCHEMBL623079 | 0.82 | HPGD (0.50) | HTTMAPTALDH1A1NPC1RAB9A | |
| SCHEMBL11252781 | 0.80 | MAPT (0.52) | HTTMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL29354416 | 0.77 | CYP1A2 (0.52) | LMNAMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL633343 | 0.77 | CYP1A2 (0.54) | LMNAHTTMEN1KMT2AMAPT | |
| SCHEMBL27837793 | 0.74 | MEN1 (0.42) | LMNAHTTMEN1KMT2AMAPT | |
| SCHEMBL11404993 | 0.74 | MEN1 (0.53) | LMNAHTTMEN1KMT2AMAPT | |
| SCHEMBL27598938 | 0.74 | MEN1 (0.48) | LMNAHTTMEN1KMT2AMAPT | |
| SCHEMBL1188690 | 0.74 | MAPT (0.53) | LMNAHTTMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5034410-A | Nitrile and oxo containing amides or thioamides | SYNTEX (U.S.A.) INC. (US) | 1991-07-23 | — | — | US | disclosed |
| US-4239888-A | 1-Phenyluracils | PFIZER INC. (US) | 1980-12-16 | — | — | US | disclosed |