Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 6/20 | 0.38 |
| ▸ | PPARD | Q03181 | 6/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | CASR | P41180 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9819001 | 1.00 | LMNA (0.39) | LMNAMAPTSMN1; SMN2NPSR1PPARG | |
| SCHEMBL9818765 | 0.84 | AKR1B1 (0.45) | MAPTPPARGPPARDAKR1B1FFAR1 | |
| SCHEMBL9818767 | 0.84 | AKR1B1 (0.45) | MAPTPPARGPPARDAKR1B1FFAR1 | |
| SCHEMBL10649219 | 0.80 | HTR2C (0.37) | LMNAMAPTSMN1; SMN2NPSR1 | |
| SCHEMBL9819041 | 0.79 | HTT (0.40) | MAPTPPARGPPARDAKR1B1FFAR1 | |
| SCHEMBL9819039 | 0.79 | HTT (0.40) | MAPTPPARGPPARDAKR1B1FFAR1 | |
| SCHEMBL7057869 | 0.78 | PPARG (0.40) | SMN1; SMN2PPARGPPARDFFAR1PPARA | |
| SCHEMBL9818919 | 0.78 | PPARG (0.38) | PPARGPPARDAKR1B1FFAR1PPARA | |
| SCHEMBL9818800 | 0.78 | PPARG (0.38) | PPARGPPARDAKR1B1FFAR1PPARA | |
| SCHEMBL9818843 | 0.77 | FFAR1 (0.46) | PPARGPPARDFFAR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0230379-B1 | CHROMAN- AND THIOCHROMAN-4-ACETIC ACIDS USEFUL IN THE TREATMENT OF DIABETIC COMPLICATIONS | PFIZER INC. (US) | 1991-04-03 | — | — | EP | disclosed |