Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 6/20 | 0.39 |
| ▸ | PPARD | Q03181 | 6/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9819039 | 1.00 | HTT (0.40) | HTTALDH1A1HPGDPPARGPPARD | |
| SCHEMBL9818762 | 0.89 | HTT (0.42) | HTTALDH1A1HPGDPPARGPPARD | |
| SCHEMBL9818756 | 0.89 | HTT (0.42) | HTTALDH1A1HPGDPPARGPPARD | |
| SCHEMBL8820474 | 0.87 | ALOX5 (0.37) | HTTALDH1A1HPGDTHRBTP53 | |
| SCHEMBL9819044 | 0.84 | LTB4R (0.43) | HTTALDH1A1HPGDPPARGPPARD | |
| SCHEMBL9819040 | 0.84 | LTB4R (0.43) | HTTALDH1A1HPGDPPARGPPARD | |
| SCHEMBL9818765 | 0.82 | AKR1B1 (0.45) | HTTALDH1A1PPARGPPARDTP53 | |
| SCHEMBL9818767 | 0.82 | AKR1B1 (0.45) | HTTALDH1A1PPARGPPARDTP53 | |
| SCHEMBL9818872 | 0.82 | ABCB1 (0.46) | HTTHPGDMTNR1APOLBAKR1B1 | |
| SCHEMBL9818878 | 0.82 | ABCB1 (0.46) | HTTHPGDMTNR1APOLBAKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0230379-B1 | CHROMAN- AND THIOCHROMAN-4-ACETIC ACIDS USEFUL IN THE TREATMENT OF DIABETIC COMPLICATIONS | PFIZER INC. (US) | 1991-04-03 | — | — | EP | disclosed |