Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | KLK7 | P49862 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23788617 | 0.89 | PBRM1 (0.54) | PBRM1ALDH1A1GAASMN1; SMN2HPGD | |
| SCHEMBL9818879 | 0.84 | PBRM1 (0.58) | PBRM1AKR1B1ALDH1A1GAASMN1; SMN2 | |
| SCHEMBL9819094 | 0.84 | PBRM1 (0.58) | PBRM1AKR1B1ALDH1A1GAASMN1; SMN2 | |
| SCHEMBL23778122 | 0.81 | HTT (0.39) | AKR1B1HPGDCYP19A1HTTPPARG | |
| SCHEMBL10713025 | 0.81 | PBRM1 (0.55) | PBRM1AKR1B1ALDH1A1GAASMN1; SMN2 | |
| SCHEMBL23188416 | 0.81 | ACHE (0.52) | PBRM1ALDH1A1GAASMN1; SMN2HPGD | |
| Lithium Ion SCHEMBL10713022 | 0.80 | PBRM1 (0.54) | PBRM1AKR1B1ALDH1A1GAASMN1; SMN2 | |
| SCHEMBL9819184 | 0.78 | PBRM1 (0.53) | PBRM1ALDH1A1GAACYP19A1KDM4E | |
| SCHEMBL9818930 | 0.78 | PBRM1 (0.53) | PBRM1AKR1B1ALDH1A1GAAKDM4E | |
| SCHEMBL9819284 | 0.78 | PBRM1 (0.60) | PBRM1AKR1B1ALDH1A1GAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0230379-B1 | CHROMAN- AND THIOCHROMAN-4-ACETIC ACIDS USEFUL IN THE TREATMENT OF DIABETIC COMPLICATIONS | PFIZER INC. (US) | 1991-04-03 | — | — | EP | disclosed |
| US-4853410-A | Hydroxyacetic acid derivatives for the treatment of diabetic complications | PFIZER INC. (US) | 1989-08-01 | — | — | US | disclosed |
| WO-1987004344-A1 | HYDROXYACETIC ACID DERIVATIVES FOR THE TREATMENT OF DIABETIC COMPLICATIONS | PFIZER INC. (US) | 1987-07-30 | — | — | WO | disclosed |
| EP-0230379-A2 | Chroman- and thiochroman-4-acetic acids useful in the treatment of diabetic complications | PFIZER INC. (US) | 1987-07-29 | — | — | EP | disclosed |