Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 2/20 | 0.64 |
| ▸ | TYR | P14679 | 1/20 | 0.60 |
| ▸ | MAOB | P27338 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | BCHE | P06276 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.52 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.52 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.52 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.51 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.51 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.51 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.51 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9819136 | 1.00 | AR (0.64) | ARTYRMAOBMAPTLMNA | |
| SCHEMBL29837087 | 1.00 | AR (0.64) | ARTYRMAOBMAPTLMNA | |
| SCHEMBL1659468 | 0.85 | TYR (0.77) | TYRMAOBMAPTRAB9ACYP1B1 | |
| SCHEMBL1659465 | 0.85 | TYR (0.77) | TYRMAOBMAPTRAB9ACYP1B1 | |
| SCHEMBL13776889 | 0.85 | NFE2L2 (0.56) | ARTYRMAOBMAPTLMNA | |
| SCHEMBL10341663 | 0.84 | TYR (0.60) | TYRMAOBMAPTLMNABCHE | |
| SCHEMBL10341664 | 0.84 | TYR (0.60) | TYRMAOBMAPTLMNABCHE | |
| SCHEMBL27940683 | 0.84 | CYP1B1 (0.69) | TYRMAOBMAPTLMNABCHE | |
| SCHEMBL3598076 | 0.83 | APP (0.64) | ARMAPTLMNACYP1B1CAPN1 | |
| SCHEMBL3598073 | 0.83 | APP (0.64) | ARMAPTLMNACYP1B1CAPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114890975-B | Compound with fused ring chroman structure and preparation method thereof | 合肥工业大学 | 2023-07-18 | — | — | CN | claimed |
| EP-0230379-B1 | CHROMAN- AND THIOCHROMAN-4-ACETIC ACIDS USEFUL IN THE TREATMENT OF DIABETIC COMPLICATIONS | PFIZER INC. (US) | 1991-04-03 | — | — | EP | disclosed |
| US-4853410-A | Hydroxyacetic acid derivatives for the treatment of diabetic complications | PFIZER INC. (US) | 1989-08-01 | — | — | US | disclosed |
| WO-1987004344-A1 | HYDROXYACETIC ACID DERIVATIVES FOR THE TREATMENT OF DIABETIC COMPLICATIONS | PFIZER INC. (US) | 1987-07-30 | — | — | WO | disclosed |
| EP-0230379-A2 | Chroman- and thiochroman-4-acetic acids useful in the treatment of diabetic complications | PFIZER INC. (US) | 1987-07-29 | — | — | EP | disclosed |