Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.30 |
| ▸ | NOS1 | P29475 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8199270 | 0.72 | SMN1; SMN2 (0.41) | SMN1; SMN2LMNAALDH1A1HPGDRAB9A | |
| SCHEMBL13155068 | 0.71 | ALDH1A1 (0.44) | SMN1; SMN2ALDH1A1NPC1HPGDRAB9A | |
| Bicarbonate SCHEMBL10361296 | 0.67 | NPC1 (0.49) | SMN1; SMN2LMNAALDH1A1NPC1HPGD | |
| SCHEMBL2798343 | 0.67 | MAPT (0.44) | SMN1; SMN2ALDH1A1NPC1HPGDRAB9A | |
| SCHEMBL8872085 | 0.67 | — | — | |
| SCHEMBL2798339 | 0.67 | MAPT (0.44) | SMN1; SMN2ALDH1A1NPC1HPGDRAB9A | |
| SCHEMBL8871865 | 0.67 | — | — | |
| Hydrochloric Acid SCHEMBL8873273 | 0.66 | — | — | |
| Acetic Acid SCHEMBL3602202 | 0.66 | NPC1 (0.48) | SMN1; SMN2LMNAALDH1A1NPC1HPGD | |
| SCHEMBL3155742 | 0.66 | LMNA (0.37) | SMN1; SMN2LMNAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0358092-B1 | 2-AZA-4-(ALKOXYCARBONYL)SPIRO-(4,5)DECAN-3-ONE | LONZA A.G. (CH) | 1991-12-11 | — | — | EP | disclosed |
| EP-0358092-A1 | 2-Aza-4-(alkoxycarbonyl)spiro-(4,5)decan-3-one | LONZA A.G. (CH) | 1990-03-14 | — | — | EP | disclosed |