Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21490441 | 0.74 | TDP1 (0.38) | KDM4EALDH1A1APOBEC3AAPOBEC3GACHE | |
| SCHEMBL5322137 | 0.72 | ALDH1A1 (0.46) | KDM4EMEN1ALDH1A1HPGDAPOBEC3A | |
| Hydrochloric Acid SCHEMBL11541165 | 0.71 | POLB (0.36) | KDM4EMEN1ALDH1A1HPGDAPOBEC3A | |
| Hydrochloric Acid SCHEMBL11230497 | 0.70 | KCNH2 (0.40) | KDM4EMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL29018989 | 0.69 | MAPT (0.33) | KDM4EMEN1ALDH1A1HPGDAPOBEC3A | |
| Hydrochloric Acid SCHEMBL1717299 | 0.69 | CYP2D6 (0.38) | KDM4EMEN1ALDH1A1HPGDAPOBEC3A | |
| Hydrochloric Acid SCHEMBL7599736 | 0.67 | POLB (0.62) | KDM4EMEN1ALDH1A1KMT2AACHE | |
| SCHEMBL149591 | 0.67 | CYP2D6 (0.39) | KDM4EMEN1ALDH1A1HPGDAPOBEC3A | |
| Bromide SCHEMBL1652337 | 0.66 | CYP2D6 (0.38) | KDM4EMEN1ALDH1A1APOBEC3AKMT2A | |
| SCHEMBL1827048 | 0.65 | POLB (0.64) | KDM4EMEN1ALDH1A1KMT2AACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5009880-A | Mixture of an anionic and cationic polymer for shampoos, skin lotions, nail strengtheners and hair dyeing; improved fixing and anchoring; smoothness; gloss | L'OREAL (FR) | 1991-04-23 | — | — | US | disclosed |
| US-4719099-A | ANIONIC AND CATIONIC | L'OREAL (FR) | 1988-01-12 | — | — | US | disclosed |
| US-4445521-A | ANIONIC AND CATIONIC POLYMER COMBINATION | L'OREAL (FR) | 1984-05-01 | — | — | US | disclosed |
| US-4240450-A | HAIR CONDITIONER OF ANIONIC POLYMERS AND CATIONIC POLYMERS | L'OREAL (FR) | 1980-12-23 | — | — | US | disclosed |