Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | MMP3 | P08254 | 1/20 | 0.31 |
| ▸ | MMP8 | P22894 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4365735 | 0.87 | MMP1 (0.35) | KMT2ACA12CA7CA14MMP1 | |
| SCHEMBL9869777 | 0.85 | TSHR (0.33) | TSHRKMT2AUSP2 | |
| SCHEMBL8721057 | 0.79 | KMT2A (0.43) | TSHRKDM4EHSD17B10KMT2AALDH1A1 | |
| SCHEMBL11417319 | 0.79 | TSHR (0.34) | TSHRKMT2ACA12CA7CA14 | |
| SCHEMBL11134004 | 0.79 | MMP1 (0.35) | KMT2ACA12CA7CA14MMP1 | |
| SCHEMBL9819676 | 0.77 | GAA (0.30) | — | |
| SCHEMBL28228681 | 0.76 | MMP1 (0.39) | TSHRKDM4EHSD17B10CASP1ALDH1A1 | |
| SCHEMBL18426999 | 0.75 | MMP1 (0.33) | CA12CA7CA14MMP1MMP3 | |
| SCHEMBL20473220 | 0.75 | MMP1 (0.42) | TSHRKMT2ACA12CA7CA14 | |
| SCHEMBL8505349 | 0.74 | TSHR (0.36) | TSHRKDM4EHSD17B10KMT2ACASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5034376-A | Nor-statine and nor-cyclostatine polypeptides | PFIZER INC. (US) | 1991-07-23 | — | — | US | disclosed |
| US-4935405-A | Nor-statine and nor-cyclostatine polypeptides | PFIZER INC. (US) | 1990-06-19 | — | — | US | disclosed |
| US-4814342-A | Nor-statine and nor-cyclostatine polypeptides | PFIZER INC. (US) | 1989-03-21 | — | — | US | disclosed |