Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 2/20 | 0.57 |
| ▸ | CTSK | P43235 | 2/20 | 0.57 |
| ▸ | REN | P00797 | 13/20 | 0.45 |
| ▸ | CTSD | P07339 | 1/20 | 0.43 |
| ▸ | CTSE | P14091 | 1/20 | 0.43 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9819695 | 0.87 | CTSS (0.56) | CTSSCTSKRENCTSDCTSE | |
| SCHEMBL7872157 | 0.87 | CTSS (0.56) | CTSSCTSKRENCTSDCTSE | |
| SCHEMBL5847958 | 0.87 | CTSS (0.56) | CTSSCTSKRENCTSDCTSE | |
| SCHEMBL13134807 | 0.87 | CTSS (0.56) | CTSSCTSKRENCTSDCTSE | |
| SCHEMBL10407741 | 0.87 | CTSS (0.53) | CTSSCTSKRENCTSDCTSE | |
| SCHEMBL7311968 | 0.87 | CTSS (0.56) | CTSSCTSKRENCTSDCTSE | |
| SCHEMBL7401954 | 0.87 | CTSS (0.56) | CTSSCTSKRENCTSDCTSE | |
| SCHEMBL9515615 | 0.86 | CTSS (0.52) | CTSSCTSKRENCTSDCTSE | |
| SCHEMBL8621724 | 0.86 | CTSS (0.52) | CTSSCTSKRENCTSDCTSE | |
| SCHEMBL13134798 | 0.86 | CTSS (0.52) | CTSSCTSKRENCTSDCTSE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5034376-A | Nor-statine and nor-cyclostatine polypeptides | PFIZER INC. (US) | 1991-07-23 | — | — | US | disclosed |
| US-4935405-A | Nor-statine and nor-cyclostatine polypeptides | PFIZER INC. (US) | 1990-06-19 | — | — | US | disclosed |
| US-4814342-A | Nor-statine and nor-cyclostatine polypeptides | PFIZER INC. (US) | 1989-03-21 | — | — | US | disclosed |
| EP-0266950-A2 | Nor-statine and nor-cyclostatine polypeptides | PFIZER INC. (US) | 1988-05-11 | — | — | EP | disclosed |